Endocrine Abstracts

Objective: A descriptive study to summarize the experience on diagnosis of NET using various imaging modalities.Methods: Imaging was reviewed for 25 patients between 2002 and 2009 (22 MEN-1, 3 sporadic insulinoma). Of 13/25 had elevated fasting gut hormones. CT, MRI, endoscopic ultrasound (EUS), somatostatin receptor scintigraphy (SRS) and angiography were reviewed. (CT, MRI examined with arterial enhancement).Results: Most frequen...

Context: Prolactinomas are the most common functioning pituitary adenomas & it is recognised that gender has an influence on presentation and management of this condition.Objective: To examine the effects of gender on presentation and response to treatment in a large cohort of adults with confirmed prolactinoma (MRI performed and macroprolactin excluded).Design & patients: This retrospective cohort study design used an elec...

A 19-year-old, female of West African descent presented with a 5 months history of thyrotoxicosis. The GP had commenced carbimazole. She had continuing clinical and biochemical thyrotoxicosis TSH <0.01 (0.3–5.5 mU/l), FT4 68.0 (9–20 pmol/l) and FT3 18.9 (3.4–5.6 pmol/l). Thyroid antibodies were present at elevated titre and technetium uptake scanning showed toxic diffuse hyperplasia with an uptake function of 37%, confirming Graves&#146...

Ergot derived dopamine agonist therapy (EDDAT) has recently been associated with fibrotic cardiac valvulopathy in patients with Parkinson’s disease. These patients received a cumulative dose of 2800–6700 mg of cabergoline for an average duration of two years. This has raised concerns about the use of these agents in patients with prolactinomas and has led to the recent EMEA/MHRA guidance that all patient being treated with EDDA should undergo surveillance echocardiog...

Background: Withdrawal of dopamine agonist (DA) therapy in the management of microprolactinoma is common practice. It is unclear however which patients are likely to attain long term remission.Aims: The aim of this prospective study was to identify clinical factors that might predict long term remission.Subjects: Fourty subjects (39 female, aged 24–60 years) with microprolactinoma; all had been normoprolactinaemic on DA therap...

Patients with craniopharyngioma are frequently obese with a high prevalence of vascular morbidity. Many patients with treated craniopharyngioma have severe GH deficiency (GHD), which independently results in abnormal body composition and increased cardiovascular risk. This study investigated how GH treatment influences body composition in adults with treated craniopharyngioma and GHD.Using the electronic database Diabeta3® we identified 50 patients ...

Adrenal incidentalomas are tumours of the adrenal incidentally discovered during evaluation for non-adrenal disease. The National Institute of Health consensus definition usually excludes lesions found during evaluation for malignancy. We present a case of an initially non-secretory adrenal incidentaloma that progressively increased in size over 6 years and became hormonally active.A 78-year-old hypertensive male was found to have a right adrenal mass du...

Recently updated international guidelines recommend specialist surveillance of adults with Turner Syndrome (TS). In 2005, we established a dedicated TS clinic, attracting referrals from our general endocrine service and other specialities including primary care.Twenty-three patients currently attend of whom 9 were previously under endocrinology review. Karyotypes include 45XO (8/23), 45XO/46XrX (4/23), and 45XO/46XiXq (3/23). Mean (±S.D.</sma...

The route of oestrogen replacement has an important influence on growth hormone (GH) sensitivity, but it remains unclear whether the route of testosterone treatment in hypopituitarism influences the response to GH replacement. We have compared IGF-I levels, body composition and BMD in hypopituitary male patients with severe GH-deficiency receiving either oral testosterone undecanoate (T.U.)(80-160 milligrams per day) or intramuscular testosterone (I.M.) (250-500 milligrams per...

We recently reported the impact of continous s.c. hydrocortisone infusion (CSHI) on weight, patient AddiQoL scores and healthcare cost savings on five patients. This poster is to follow up on all our patients experiences since started on the CSHI as well as qualitative feedback on the impact on their lives.This poster also gathered key points on how these patients managed their adrenal crisis....