Endocrine Abstracts

Background: McCune Albright Syndrome (MAS) is a rare mosaic disease caused by activating mutation in GNAS, characterized by bone fibrous dysplasia, café au- lait (CAL) and hyper functional endocrinopathies (1). GIPP is the most common endocrinologic manifestation seen more frequently in girls (2). In a few studies, letrozole, tamoxifen, or fulvestrant were effective in decreasing the rate of skeletal maturation and vaginal bleeding (3,4,5).Case Repo...

Introduction: Type 2 diabetes mellitus (T2DM) is associated with urological and endocrine complications, including erectile dysfunction (ED) and hypogonadism.Aim: REVITALISE was conducted to assess men with/without T2DM at risk of ED and/or hypogonadism, and highlight gaps in current clinical management.Methods: Data were collected from 13 UK primary care practices on incidence of ED, hypogonadism (defined as serum total testostero...

We report the case of a 59-year-old male who presented complaining of several weeks of tiredness, poor appetite and dizziness on standing. He had been treated with flucloxacillin by his GP for otitis externa one week earlier.In 1982, he was diagnosed with nasopharyngeal carcinoma in Hong Kong, which was treated by radical dissection and radiotherapy.On examination, his standing and lying blood pressure were 150/100 and 110/90 respe...

QLS-H is a new, weighted QoL questionnaire developed for patients with hypopituitarism. We evaluated QLS-H data from UK patients in the HypoCCs International surveillance study, and compared results with a sample of the general UK population (n=1090).The QLS-H questionnaire was administered at baseline and at yearly intervals. Scores were corrected for age and gender differences, and expressed as Z-scores based on UK-specific reference ranges. Using this...

Case History: A 23-year-old Bengali woman with a 2-year history of Graves’ disease presented to the endocrine day unit with a widespread, pruritic, vasculitic-looking rash. She was treated with Carbimazole since diagnosis but was poorly compliant. One month prior to presentation, her Carbimazole dose was increased from 20 mg daily to 60 mg daily, as she remained biochemically thyrotoxic (Free T4 79.9 pmol/l, T3 34.8 pmol/l and TSH < 0.01 mU/l). The rash started on her lower...

A 34-year old lady presented in the postpartum period following her 3rd pregnancy with severe hypertension. Her first two pregnancies were 3 and 5 years previously where she delivered via elective Caesarean section without any complications. During this pregnancy which was a twin pregnancy, her antenatal care was mainly unremarkable but on specific questioning, she reported increased sweating for a period of 4 months. Her blood pressure was noted to be normal during her antena...

Prostate cancer is the most common male cancer in the UK. Currently there is a lack of pre-clinical models to predict patient’s response to treatment for prostate cancer. Identifying which patients will respond best to treatment avoids exposing patients to treatment side effects unnecessarily. Primary cell culture provides a translational model to predict individual patient’s response to drug treatments. In this study, we develop a technique for isolation, propagatio...

Background: Acromegaly treatment options include transsphenoidal surgery (TSS), medical management with somatostatin analogues (SSAs), growth hormone (GH) receptor antagonists and dopamine agonists, radiotherapy or a combination of these, depending on symptom nature and severity, tumour size, age and health status. In 2014 the Endocrine Society published guidelines for management of acromegaly.Methods: To describe current UK practice following guideline ...

Background: Secondary hyperparathyroidism is a common complication of established renal failure (ERF) and is associated with significant morbidity and mortality. The aims of this study were to determine patient and operative characteristics, which might predict persistent or recurrent hyperparathyroidism after surgery. To assess the influence of pre-operative imaging on the ability to locate and remove parathyroid glands during both the initial and repeat surgery and to assess...

The majority of adult GH replaced patients reach target IGF1 levels using established injection devices. However, a small but significant cohort of these patients fail to achieve these intended goals. This can be manifested as either a failure to improve (biochemically or symptomatically) despite escalating GH doses, or large variations in IGF1 measurements despite steady GH dosing.The Easypod® device has a memory chip which allows record...