Endocrine Abstracts

Background: The presence of striking cardiovascular manifestations was noted in the first descriptions of hyperthyroidism owing to Parry (1825) and Basedow (1840) in the famous Merseburger triad. Hyperthyroidism may either cause cardiac complication in individuals with a normal myocardium (genuine form of disorder) or complicate pre-existing cardiac troubles.Patients and methods: An homogenous series of 49 cardiothyreosis, 11 males and 38 females, aged 1...

Background: Cholesterol is a major component of the cell membrane. It plays an important role in its physiology affecting vital properties, such as membrane fluidity, cation transport, cell receptors, osmotic resistance etc. Abnormal conditions that change serum cholesterol concentration (SC) can also alter erythrocyte membrane cholesterol concentration (EMCC) possibly resulting in differentiation of several membrane functions.Aim: To investigate whether...

Background: The aim of this case report is to underline the possible etiological link between paroxysmal supraventricular tachycardia (PSVT) and hypothyroidism, although supraventricular arrhythmias are ordinary features of hyperthyroidism. We present the case of a patient with repetitive episodes of PSVT whose autoimmune hypothyroidism was diagnosed and thyroxin replacement therapy leaded to remission of arrhythmia.Methods: A 47 year old women with a lo...

Background: Glucocorticoid resistance syndrome is a rare, familial or sporadic disease, caused by genetic mutations of the glucocorticoid receptor or at any other level of the signaling pathway. It is characterized by general, partial, target-tissue insensitivity to glucocorticoids, leading to activation of the hypothalamo–hypophysis–adrenal axis resulting in compensatory increased levels of cortisol, but also increased concentrations of adrenal products with mineral...

Thyroglobulin (Tg) is a tumoral marker of differentiated thyroid cancer (DTC). Iterative Tg assays are then mandatory for their follow-up. The maximum imprecision of any Tg measurement should be <5%. However, it is unlikely that current Tg assays can maintain such tight precision over the 6–12 months time period used for monitoring patients with DTC. This precision can be overcome by measuring archived frozen samples from the patient in the same run as the current spe...

Background: Metabolomics profiling of bio-fluids suggests altered signatures in patients with the polycystic ovary syndrome (PCOS).Subjects and methods: A high-performance liquid chromatography/time-of-flight mass spectrometry (HPLC/TOF-MS)-based metabolomics approach was developed to characterize the untargeted lipidomics signature associated with PCOS status in a discovery cohort of 30 plasma samples (15 PCOS, 15 controls, age-matched), followed in a s...

Introduction: Atheromatous plaque instability biomarkers are the most important predictors for the evolution with major acute cardiovascular events (MACE) in patients with NSTE-ACS.Objective: To evaluate the impact of dyslipidemia, endothelial dysfunction, oxidative stress, platelet hyperactivity and hypercoagulable state and their inter-correlation on the outcome of NSTE-ACS.Methods: Two hundred and forty patients with NSTE-ACS, 1...

The adrenal function of children is investigated similarly to adults’ using at rest (basal) and after testing serum cortisol concentration ((F)). di Iorgi et al. (JCEM 95:2132) showed a good diagnostic accuracy of glucagon testing investigating (F) increase. We retrospectively addressed the relevance of using, in children with short stature tested for GH deficiency, 1/ the normal reference range of our assay for basal (F) and 2/ the threshold provided by di Iorgi et al. o...

Introduction: Type 1 diabetes secondary osteoporosis is an underdiagnosed condition and there are few studies that addressed the topic of clinical risk factors in this context, although, for a better diagnosis and management, it is of great importance to find such predictors.Aim: To evaluate bone mineral density and parameters of bone metabolism in patients with type 1 diabetes in comparison with a group of healthy subjects and to determine possible risk...

One of the causes of secondary osteoporosis is type 1 DM (1DM), an autoimmune disease where insulin replacement is mandatory for controlling blood sugar levels. Among the mechanisms involved in osteoporosis in 1DM is increased bone resorption, mainly osteoclasts being responsible for this process. However, osteoblasts also seem to have an active contribution by secreting products with resorptive properties, one of these being cysteine protease Cathepsin K, as mentioned by a fe...