Endocrine Abstracts

Introduction: GH neurosecretory dysfunction (NSD) refers to children with abnormal auxology, normal GH responses to provocative testing, but with impaired spontaneous GH secretion over 24 h, leading to low IGF1 concentrations. It is thought to be due to abnormal hypothalamic function with aberrant GHRH and somatostatin secretion leading to impaired GH secretion and subsequently suboptimal growth.Methods: We reviewed children admitted for spontaneous GH s...

Introduction: The 2006 Endocrine Society – testosterone therapy in adult men guidelines were audited against the clinical practice at a UK teaching hospital endocrine department. The aim of the audit was to determine whether patients were undergoing appropriate screening tests for prostate cancer and polycythaemia as described in these guidelines.Method: Patients were initially identified by searching the endocrine clinic letter database for the nam...

Background: The UK has advocated a policy of screening children’s growth opportunistically. Such a policy has merit if measurements are performed and the data easily retrieved to enable a possible referral for specialist assessment.Height measuredWeight measured N...

The epidemic of obesity, insulin resistance and type 2 diabetes has heightened the need to understand the mechanisms that contribute to their pathogenesis. Endogenous glucocorticoid (GC) production and metabolism have been implicated based upon parallels with Cushing’s syndrome. The interaction between GC metabolism and insulin sensitivity in the context of significant weight loss has not been explored. 11β-hydroxysteroid dehydrogenase type 1 (11β-HSD1) that gen...

Introduction Adrenal myelolipomas are rare small benign tumours composed of mature fat and hemopoietic tissues, which can be associated with congenital adrenal hyperplasia (CAH). We report a rare case of massive bilateral adrenal myelolipomas.Case report A 48 year old gentleman with CAH diagnosed during childhood presented at a routine endocrine appointment. He had not regularly attended his appointments or taken his steroids f...

Introduction Adrenal myelolipomas are rare small benign tumours composed of mature fat and hemopoietic tissues, which can be associated with congenital adrenal hyperplasia (CAH). We report a rare case of massive bilateral adrenal myelolipomas.Case report A 48 year old gentleman with CAH diagnosed during childhood presented at a routine endocrine appointment. He had not regularly attended his appointments or taken his steroids f...

DOTA (1,4,7,10-tetraazacyclododecane-1,4,7,10-tetraacetic acid)−peptide (DOTA peptide) seen on positron emission tomography combined with computed tomography (68Ga-DOTA PETCT) has been proven to be one of the most accurate methods of imaging NETs. The first stage in the accurate reporting and utilising DOTA PETCT is a clear understanding of the normal patterns. PNETs can present with focal DOTA peptide uptake on imaging. We present preliminary data of a retros...

Introduction: Adolescents with type 1 diabetes often have poor control causing them significant future danger. An area of particular concern is that of worsening control around the complex time of transition to young adult services from paediatric services. Multiple guidelines and methods to help better this control and transition process are in place.Aim: This study aims to survey attitudes towards and possible improvements to clinics to aid adherence a...

A 38 year old lady presented at 30 weeks gestation with a 3 week history of headaches and 5 day history of blurring of vision, worse in the left eye. Visual field testing revealed a bitemporal hemianopia. MRI scan of the pituitary showed appearances typical of a macroadenoma which was lobulated in appearance with suprasellar extension (max height 13mm) and compression of the optic chiasm. Endocrine tests indicated that thyroxine was low for the 3rd trimester (79nmol/l), with f...

Gonadal dysgenesis (GD) is characterised by maldevelopment of the gonads and is classified as complete (CGD) or partial (PGD) depending on gonadal morphology and function. The phenotype of PGD is variable and diagnosis is based on clinical and biochemical features, coupled with gonadal histology and genetic findings. “46,XY Gonadal Dysgenesis: diagnosis and long-term outcome” has recently been approved as an I-DSD Registry-based study. The aim is to characterise the ...