Endocrine Abstracts

Biological significance of microelements depends on concentration and interaction between them. Children are more sensitive to micronutrients imbalance. The aim was to estimate the microelement imbalance influence on the thyroid gland function and physical, mental and intellectual development of the children.Growth and weight were estimated by CDC 2000, psychological status from birth by the skills and speech development, from 8 years by Luscher, Kos, Sc...

Background: Adrenocortical carcinoma (ACC) is an uncommon endocrine malignancy, usually characterized by a late detection, aggressive clinical course, and poor outcome. The tumor microenvironment (TME) which includes infiltrating immune cells plays a critical role in tumor growth, survival, and prognosis in cancer patients. The presence of tumor-infiltrating immune cells (TIIC) affect the clinical benefit from novel strategies of immunological checkpoint blockade. Anti-immune ...

Introduction: The incidence of adrenal incidentalomas is 5% among patients undergoing radiological imaging. Differential diagnosis is extremely important, as it determines the tactics of both therapeutic treatment and surgical intervention. Currently, algorithms for the differential diagnosis of adrenal masses have been developed and are widely used. Nevertheless, the compliance with strictly regulated diagnostic protocols does not always allow to make an accurate diagnosis.</...

Poor hormonal and tumour responses to somatostatin analogues (SSA) in acromegaly can occur although the aetiology is often unclear. Two genetic syndromes are associated with relative SSA resistance: acromegaly due to AIP mutations (AIPmut) and the newly described X-linked acrogigantism (X-LAG) syndrome due to chromosome Xq26.3 microduplications. We studied whether SSA resistance in these conditions was related to somatostatin receptor (SSTR) levels in tumour tissues. We studie...

Objective: To evaluate the chance of developing new cases of Type 2 diabetes mellitus (DM) in obese people in the population sample of the city of Novosibirsk aged 45–69 years.Materials and methods: The analysis included 2464 people, including 586 (23.7%) men and 1878 (76.2%) women without DM. This sample was formed from the base of the international project HAPIEE surveyed from 2003 to 2005. When conducting a re-screening of the same sample in 2006...

CYP11B2 is a key enzyme of primary aldosteronism, and several factors are involved in the regulation of CYP11B2 expression and the overproduction of aldosterone. Somatic mutations in aldosterone-driver genes are strongly associated with CYP11B2 expression and have been only detected in the CYP11B2-positive tumor area, indicating that aldosterone producing adenoma (APA) intratumoral heterogeneity corresponds to non-uniform CYP11B2 expression in neoplastic cells. In addition, CY...

Primary hyperparathyroidism (PHPT) is the third most frequent endocrine disorder and has a variable clinical presentation. Asymptomatic PHPT became the predominant form of the disease with increase of it’s incidence after the introduction of automated serum calcium measurement in North America and Europe. Data from Russia is lacking.Aim: To present the clinical profile of PHPT in Russia.Materials and methods: This retrospectiv...

MEN1 syndrome is an autosomal dominant inherited disease characterised by primary hyperparathyroidism in association with endocrine enteropancratic tumors and anterior pituitary adenomas. Tumours of the pituitary gland as the first manifestations of MEN1 are very rare in children.Clinical case report: A 13-year-old boy presented with clinical signs suggestive of Cushing’s syndrome. He had decreased growth rate, muscle weakness, headaches and truncal...

Introduction: Artificial hypoglycemia (AH) is the intentional administration of insulin preparations or the use of oral hypoglycemic agents to lower blood glucose levels. It is one of the variants of Munchausen’s syndrome. Hypoglycemia in non-diabetic patients is a blood glucose level of less than 3.0 mmol/l. AH among all causes of non-diabetic hypoglycemia (NDH) is approximately 4-11%. Identification of such cases is an urgent problem in the differential diagnosis of NDH...

Introduction: Prolactinomas are the most common type of pituitary adenomas(40% of them), representing a significant cause of infertility and hypogonadism. About 20% of patients with prolactinomas don’t respond satisfactory(i.e. resistant) even to high dose dopamine agonist(DA) treatment(>3.5–4.5 mg/week). Worth noticing that there are no clear signs to anticipate this resistance but to stepwise increase the dose of DA. In addition, the etiology of resistance &#15...