Endocrine Abstracts

Purpose: Recently, apatinib, an orally anti-angiogenic tyrosine kinase inhibitor (TKI) is reported to be useful for treatment of progressive RAIR-DIC. The aim of this study was to evaluate the effect of apatinib and the combination therapy with radioactive iodine (RAI) in patients with progressive metastatic DTC.Methods: Five patients (all female mean age 62 ± 8 years, ranged from 51 to 69 years) with progressive distant metastatic DTC (dmDTC) after t...

Introduction: Maternally inherited diabetes and deafness (MIDD) that is caused by a pathogenic variant in mitochondrial DNA (mtDNA) can cause different phenotypes based on percent heteroplasmy load, with higher mutation load corresponding with disease severity. The m.A3243G mutation causes either classic MELAS or MIDD that is a partial form. The condition is characterised by diabetes, hearing impairment and maculopathy but can have several other clinical manifestations. Early ...

Introduction: The interaction between corticosteroids and protease inhibitors (PIs) is a clearly described drug interaction.Case report: A 44-year-old woman diagnosed with HIV category B3 diagnosed in 1989; severe lipodystrophy. In addition , HCV genotype IA. Bronchial asthma since 2000. Treatment with fluticasone 1 inh/24 h, salbutamol on demand, darunavir 800 mg/day and ritonavir 100 mg/day. He had known lipodystrophy since 2001 and the abdominal perim...

Aim: To compare the effectiveness and tolerability of Exenatide twice daily treatment of obese and morbidly obese type 2 diabetic (T2D) patients.Material and methods: To analyze data of obese and severe obese T2D patients initiated on Exenatide in our Endocrine clinics who complete one year of treatment. We separate patients in two groups: group A (BMI<40 kg/m2) and group B (BMI≥40 kg/m2). We did not include any modificati...

Context: There is no data on mortality of acromegaly diagnosed in the elderly. Objective: To compare clinical characteristics, GH-related comorbidities, therapeutic approaches and mortality of patients diagnosed before or after 2010 and to assess overall mortality compared with the general Spanish population. Setting: Spanish tertiary care centers.Design, Patients, and Methods: Retrospective evaluation of 118...

Purpose: To evaluate the prevalence of autonomous cortisol secretion (ACS) in patients with primary aldosteronism (PA) and its implications on cardiometabolic and surgical outcomes.Methods: A retrospective multicenter study of PA patients who underwent 1mg-dexamethasone suppression test (DST) in follow-up in 21 Spanish tertiary hospitals. ACS was defined as a cortisol post-DST >1.8μg/dL (confirmed ACS if >5μg/dL and possible ACS if between 1.8-...