Endocrine Abstracts

A 60 year old Caucasian woman was referred to endocrine clinic with persistent hypercalcaemia between 2.8 and 2.9 mmol/l (2.2–2.6), with inappropriately normal PTH at 7 pmol/l (1.48–7.63). Her hypercalcaemia was noted first in 2008. She had no signs or symptoms associated with hypercalcemia. However, she has a strong family history of hypercalcaemia, where her mother required Cinacalcet to control her hypercalcaemia despite two previous parathyroid resections. She ha...

Background: Gonadotroph adenomas are the most common non-functioning pituitary adenomas in adult1, 2. However, functioning gonadotrophinomas are rare. Here, we describe an unusual presentation of concurrent acromegaly and functioning FSHoma (FSH-secreting pituitary adenoma).A 39-year-old man presented with a vague visual disturbance to the optometrist and a bitemporal hemianopia was detected.Further questioning elicited ...

Introduction: Autoimmune thyroiditis is rarely painful. A tender goitre usually indicates viral thyroiditis. Here, we present a case of a persistent painful goitre due to sclerosing-type Hashimoto’s thyroiditis.Case presentation: Our patient is a 27-year-old mother, with no significant past medical history. She was diagnosed with autoimmune hypothyroidism in October 2005 when 4 months post-partum. At diagnosis her anti-TPO titre was 2041 U/ml...

Case history: A frail 79 years old lady with dementia presented with frequent falls since 2 years ago. Neurologist’s assessment had attributed her fainting episodes to migraine. She later was found to have biochemically evident recurrent hypoglycaemia requiring multiple admissions and eventually continuous glucose infusion to maintain euglycemia.Investigations: The severe spontaneous hypoglycaemia in this non-diabetic lady prompted investigations. T...

A 48 years old lady with BMI of 46kg/m2 was postmenopausal since age 45. Due to abdominal discomfort she had an abdominal CT, which incidentally identified bilateral adrenal adenoma (9 mm on right, 18 mm on left, with fat content). This resulted in Endocrinology referral and a history of gradually worsening hirsuitism was uncovered. Her hyperandrogenism was confirmed biochemically with markedly elevated testosterone at 6.5 nmol/l (0.0–1.8), leading to a search ...

Background: In a vast majority of cases, hypopituitarism is caused by a tumour or a vascular event of the pituitary gland. We present a case of hypopituitarism caused by an uncommon cause identified on imaging studies.Case: A 58-year-old Caucasian woman presented with a 2-day history of diplopia, headache and vomiting with a background history of tiredness and lethargy over the past 4–6 months. Past medical history included type-II diabetes, hyperte...

Background: Prolactinomas are the most common functioning pituitary tumours, accounting for 40% of all pituitary adenomas. Prolactinomas may enlarge in pregnancy, the management of which may prove challenging. Case Presentation: A 23 year old lady was referred to the endocrine clinic with secondary amenorrhoea and bifrontal headaches in 2012. Biochemical tests on referral revealed: FT4- 5.8 pmol/l, TSH-1.1 mU/l, Prolactin-4432 mIU/l, LH- 4.8 IU/l, FSH- 4...

History: A 52-year-old woman was referred by her GP for colonoscopy in view of 7 months” history of unexplained weight loss of nearly 2.5 stones, constipation and recently detected normocytic anaemia. Her past medical history was unremarkable except for bronchial asthma that was managed with albuterol. However, on the day of the scheduled colonoscopy, she was noted to be hypotensive (BP- 63/38 mm Hg, heart rate 93 bpm) and was hence admitted for fluid resuscitation. Follo...

Section 1: Case history: A 46-year-old woman was referred to the Endocrinology clinic for evaluation of persistently elevated parathyroid hormone levels despite correction of previous vitamin D deficiency. She had a history of calcific tendinitis of the left shoulder and iris pigment dispersion syndrome. Notably, her mother had undergone two parathyroid surgeries for primary hyperparathyroidism with removal of three parathyroid glands, revealing multiple parathyroid adenomas a...

Case history: A 32 female was referred to a tertiary maternity unit due to hypercalcaemia and a diagnosis of primary hyperparathyroidism (PHPT). She had learning difficulties, 2 previous C-sections and was a smoker. She presented 5 years earlier to her local hospital with abdominal and leg pains, nausea, constipation and fatigue. She had undergone 2 parathyroidectomies but remained hypercalcaemic and had been managed medically with Cinacalcet when she conceived an unplanned pr...