Endocrine Abstracts

Introduction: The MEN1 is inherited as autosomal dominant trait. In MEN 1 families a deletional mechanism of the regulatory gene appears to be the base of the syndrome.Case 1: 40-year-old lady presented with a two-day history of headaches, blurred vision and funny turns, culminating in loss of consciousness and a generalised tonic-clonic seizure. Her GCS was 3; she was intubated, ventilated and referred to ICU. U+Es normal, Calcium high, phosphate low, a...

Introduction: Acute renal failure (ARF) is a rare but life-threatening complication of severe diabetic ketoacidosis (DKA) in children.Aim: To characterise the presentation, treatment and clinical course of children with DKA complicated by severe ARF requiring renal support.Method: Retrospective notes review of patients aged <16 years admitted in 2011–2016 to 3 UK regional paediatric intensive care units (St George’s H...

Objective: Determinants of why only a subset of patients with adrenal insufficiency (AI) experience recurrent adrenal crises (AC) and intercurrent illnesses are not well understood. This study aimed to identify whether residual adrenal function (RAF), defined by the peak response to a provocative test undertaken before commencing glucocorticoids, may help explain differences in prevalence.Design and Methods: Patients wit...

Using nurse led clinics (including telephone and virtual reviews) in NHS Grampian to improve patient satisfaction following a diagnosis of hyperthyroidism.Aims: To reduce waiting times for patients with hyperthyroidism, nurse led clinics were introduced. Telephone and virtual follow up reviews are offered after commencement of thyroid treatment (e.g. anti-thyroid medication or radioactive iodine (RAI)). Nurse-led thyroid clinics aim to i...

Introduction: Emerging research in 3D-bone shape has provided new insights into the pathogenesis of osteoarthritis (OA). OA patients have increased subchondral bone area, associated with higher prevalence of cartilage loss. Higher B-score, a novel, machine learning-derived OA bone biomarker, is associated with increased OA symptom severity and structural progression. Arthropathy, despite being the commonest cause of morbidity amongst acromegaly patients, remains one of the und...

Regulators are concerned about the potential for environmental chemicals such as agrochemicals and their metabolites to perturb hormone systems. This has led to recommendations for the testing of potential endocrine disrupting chemicals1. The Steroidogenesis H295R assay is an in vitro cell model used to investigate compound effects on steroid hormone biosynthesis, specifically 17β-estradiol (E2) and testosterone (T). The human H295R adreno-carcinoma ce...

Introduction: There are limited data on the effectiveness and safety of GHRT in older patients with AGHD. We compared real-world GHRT outcomes in older (aged ≥60 years) vs middle-aged (35–<60 years) adults.Methods: NordiNet® IOS (NCT00960128) and ANSWER (NCT01009905) were non-interventional studies investigating long-term effectiveness and safety of GHRT with Norditropin® (somatropin, Novo Nordisk). Safety was assessed in the ful...

Background: Endoscopic trans-sphenoidal surgery is a technical advance for treatment of pituitary tumours. We present the outcomes of patients with Acromegaly or Cushing’s disease undergoing selective pituitary adenomectomy in a regional neurosurgical centre.Methods: Retrospective cohort study August 2010-August 2017. Imaging, histology and pituitary hormone assessments were collated pre and post-operatively to...

Background: Endoscopic trans-sphenoidal surgery is a technical advance for treatment of pituitary tumours. We present the outcomes of patients with Acromegaly or Cushing’s disease undergoing selective pituitary adenomectomy in a regional neurosurgical centre.Methods: Retrospective cohort study August 2010-August 2017. Imaging, histology and pituitary hormone assessments were collated pre and post-operatively to...

Introduction: Patients with acromegaly have increased mortality, primarily related to cardiovascular/cerebrovascular disease. The objective of this study was to evaluate whether GH/IGF-1 excess increases vascular disease by adversely affecting fibrin network characteristics.Methods: In this case–control study, 40 patients with acromegaly (21 males, age 53±13 years, 45% disease remission) and 40 age and gender-matched controls were recruited. Cl...