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ea0016p83 | Bone and calcium | ECE2008

Lack of relationship between the BsmI polymorphism in the vitamin D receptor gene and the risk of glucocorticoid-induced osteoporosis in premenopausal asthmatic women on a long-term glucocorticoid therapy

Tworowska-Bardzinska Urszula , Bidzinska-Speichert Bozena , Obojski Andrzej , Lenarcik Agnieszka

Results of many studies indicate that the BsmI polymorphism in the vitamin D receptor (VDR) gene may influence bone tissue metabolism and may be useful in identifying patients at greater risk of osteoporosis. As far as long-term glucocorticoid treatment is a major risk factor for osteoporosis development, we looked for the BsmI VDR gene polymorphism and its relation to phenotypic features characterizing bone status (BMD and metabolic bone turnover) in 74 premenopausal women: 5...

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ea0014p417 | (1) | ECE2007

Is there any relationship between the BsmI polymorphism in the vitamin D receptor gene and the occurrence of glucocorticoid-induced osteoporosis in asthmatic patients with long-term glucocorticoid treatment?

Tworowska Urszula , Bidzinska-Speichert Bozena , Obojski Andrzej , Demissie Marek , Slezak Ryszard , Lenarcik Agnieszka , Milewicz Andrzej

Introduction: Results of many studies indicate that BsmI polymorphism in VDR gene may influence bone tissue metabolism and may be useful in identifying patients at greater risk of glucocorticoid-induced osteoporosis.Aim of the study: To determine frequency of polymorphic variants of VDR gene (BsmI) and its relationship to phenotypic features characterizing bone status (BMD and metabolic bone turnover).Material and methods: Followin...

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ea0011p8 | Bone | ECE2006

Is there any combined influence of the N363S polymorphism in the glucocorticoid receptor gene and the BsmI polymorphism in the vitamin D receptor gene on the occurrence of glucocorticoid-induced osteoporosis in patients with bronchial asthma?

Tworowska U , Bidzinska-Speichert B , Obojski A , Demissie M , Koper JW , Slezak R

Osteoporosis has a strong genetic component and is a common side-effect in patients with long-term glucocorticoid (GC) treatment. Vitamin D plays an important role in bone metabolism, and polymorphisms in its receptor (VDR) gene have been implicated in the pathogenesis of osteoporosis. On the other hand, variability in the sensitivity to GCs, due to polymorphic variants of the glucocorticoid receptor (GR) gene was observed in patients treated with GCs, both with regard to the ...

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Endocrine Abstracts

Lack of relationship between the BsmI polymorphism in the vitamin D receptor gene and the risk of glucocorticoid-induced osteoporosis in premenopausal asthmatic women on a long-term glucocorticoid therapy

Is there any relationship between the BsmI polymorphism in the vitamin D receptor gene and the occurrence of glucocorticoid-induced osteoporosis in asthmatic patients with long-term glucocorticoid treatment?

Is there any combined influence of the N363S polymorphism in the glucocorticoid receptor gene and the BsmI polymorphism in the vitamin D receptor gene on the occurrence of glucocorticoid-induced osteoporosis in patients with bronchial asthma?

BiosciAbstracts