Endocrine Abstracts

We present a case of 70 year-old-man, who was referred to the endocrine clinic with incidentally detected 26 mm lesion arising from the left adrenal gland suspicious of pheochromocytoma. This was detected during investigations for asymptomatic microscopic haematuria. He did not describe the typical symptoms of pheochromocytoma (episodic headaches, sweating, tachycardia), but interestingly 4–5 months previously was diagnosed with an acute onset of psychosis with paranoid d...

Background: Parathyroid hormone (PTH) is a peptide hormone consisting of 84 amino acids with residues 1–34 responsible for its biological activity. Hypoparathyroidism is a rare, complex condition with a patient predisposition toward impaired mineral homeostasis. Replacement with Natpara (PTH 1-84) requires daily injections and is still complicated by fluctuating calcium levels. An unmet need exists for a long-acting treatment that is effective. It is hypothesised that a P...

Introduction: Hypogonadism is linked to anaemia, sarcopenia and osteoporosis in men. Whereas secondary hypogonadism (SH) is biochemically indistinguishable from nongonadal illness, primary hypogonadism (PH) can be easily diagnosable by the identification of raised gonadotropins.Case Presentation: A 66-years old male with a background history of type 2 diabetes mellitus, arthritis, and hypertension was referred to the haematology services to investigate h...

Objectives: Copper-64 (64Cu, T1/2=12.7 h; Eβ+ max =0.65 MeV (17.9%); Eβ− max =0.57 MeV (39%)) is suitable for in-vivo PET imaging. Prostate specific membrane antigen (PSMA) is significantly over-expressed in undifferentiated prostate cancer tissue. We report the initial molecular imaging results with 64Cu-PSMA PET/CT in patients with prostate cancer.Methods: 64Cu labeled PSMA (mean administered ra...

Context: Recent guidelines recommend a diagnosis of adrenal insufficiency when stimulated peak cortisol level falls below 500 nmol/l. This may not be valid when using a highly specific cortisol immunoassay or cortisol measured by liquid chromatography-mass spectroscopy.Objective: Determine the diagnostic threshold for adrenal insufficiency using a highly specific cortisol assay.Design: For 4 months, all subjects having a dynamic te...

We describe an interesting case of a man who poses a significant ongoing management challenge. He presented with mild biochemical evidence of T3 thyrotoxicosis (FT3, 8.2, FT4 13.6, TSH 0.02). Carbimazole 20 mg was started and despite increasing dosage, he deteriorated significantly. He was concordant with medication. His TBII and thyroid auto-antibodies were negative. A Tc uptake scan showed reduced uptake. Prednisolone was added, thinking that he may have thyroiditis. Despite...

Aim: Acromegaly is associated with higher mortality and morbidity, and achieving disease control can be challenging. The aim of this study was to assess the morbidity and mortality associated with active acromegaly compared to patients in whom disease control was achieved.Methods: Retrospective analysis of all patients treated with acromegaly at a university hospital between 1948 and 2014 was performed. Mortality rates and development of new cardiovascul...

Background: The hypothalamic neuropeptides kisspeptin and neurokinin B (NKB) are both obligate for normal gonadotrophin secretion. Studies in patients with loss-of-function mutations in NKB signalling suggest that kisspeptin is functionally upstream of NKB, but this hierarchy is unexplored in healthy men and women. We hypothesised that kisspeptin augmentation of estrogen-induced mid-cycle LH secretion will not be abrogated by pharmacological blockade of NKB.<p class="abste...

Background: Androgens promote erythropoiesis and have been used for the treatment of anaemia. Furthermore, polycythemia is a known side effect of androgen therapy. In congenital adrenal hyperplasia (CAH), elevated adrenal androgens cause virilisation of female patients. Glucocorticoid treatment reduces androgen levels but there is a difficult balance between excess androgens and suppressed androgens due to excess glucocorticoid treatment.Aim of study: To...

Introduction: To date, psychological research on pancreatic transplantation has focused mainly on illness and quality of life. Research has been predominantly quantitative rendering it impossible to identify specific psychological issues faced by patients. Uniquely, this work considered post-transplant issues in the context of the pre-transplant psychological burden of patients with T1DM.Methods: 21 individuals with T1DM were interviewed (11 males; five ...