Endocrine Abstracts

Aim: Low BMD and atherosclerosis may share similar underlying biological mechanisms including higher serum phosphate and inflammation. Neutrophil-lymphocyte ratio (NLR) as a simple marker of inflammation. There are scarce data indicating improved atherosclerosis and cardiovascular events with biphosphonate and teriparatide therapy. We aimed to evaluate NLR before and after 6 months of teriparatide therapy in patients with severe established osteoporosis....

Gerbil (Meriones unguiculatus) a non traditional laboratory model with reproductive state influenced by photoperiod, was used to analyze those photoperiodic mechanisms involving reproductive regulation. The 14:10 photoperiod has been widely used for reproductive research since 1950 (Everett). As is well known gerbils locomotor activity cycle has been reported to be crepuscular and reproductive cycle presents two annual peaks. As for the estrous cycle (EC), it has been...

Hypercalcaemia is one of the common cases seen in Endocrine clinics. We report another challenging case of hypercalcaemia. A 43 old Asian man was referred by GP initially in 2011 with asymptomatic hypercalcaemia of 2.87 mmol/L. His past medical history included chronic plaque psoriasis with arthropathy, hypertension, stage 3 CKD, Fatty liver with mild fibrotic change secondary to methotrexate and learning difficulties. Hypercalcamia was thought to be contributed by Dovonex (Ca...

We are presenting a case report of 82-year-old patient admitted at Cork University Hospital on 3 July 2015 for investigation of complete ptosis and ophthalmoplegia of left eye which had occurred in couple of weeks time. Initially patient was referred to ophthalmology department by his GP and ophthalmologist found left ophthalmopathy with complete ptosis and referred patient to medical for stroke work up. CT Brain showed abnormal mass in pituitary fossa. MRI Pituitary showed mu...

We present a 3-month-old boy who was born at term, to non-consanguineous parents by spontaneous vaginal delivery, weighing 4.19 kg. Newborn examination, including eyes, was normal. He was admitted at 7 days of life with focal seizures and hypocalcaemia, hypomagnesaemia, hyperphosphataemia, and inappropriately low parathyroid hormone (PTH) levels. He was treated with i.v. calcium and magnesium infusions and discharged on oral calcium, magnesium, and alfacalcidol. He was re-admi...

Background: Heterozygous loss of function glucokinase mutations causes MODY with fasting hyperglycaemia (>5.5 mmol/l). We report a 2 year girl with a glucokinase mutation who presented unusually with stress induced hyperglycaemia and normal fasting blood glucose levels.Case report: She presented with wheeze and was started on Salbutamol. Her blood glucose rose to 16 mmol/l with ketonuria. The hyperglycaemia was disproportionate to the severity of the...

Phaeochromocytoma during pregnancy is extremely rare with a frequency of 0.002% pregnancies. However, the risks for the pregnant patient with this tumour are extremely high: with maternal and foetal mortality up to 50% if undiagnosed. In contrast, early diagnosis and treatment during pregnancy decrease the maternal and foetal mortality to <5 and 15% respectively.A 37-year-old female underwent abdominal imaging to investigate iron deficiency anaemia. ...

A 60-year-old man presented with symptomatic primary hyperparathyroidism. At this time serum corrected calcium was 3.1 mmol/l (2.15–2.65 mmol/l) and after investigation bilateral parathyroid exploration was performed. A suspected adenoma was identified in the right inferior gland and removed. The remaining glands appeared normal. The adenoma was confirmed histologically. Early post-operative calcium was normal (2.48 mmol/l).He remained well and calc...

Proton pump inhibitors (PPI) are widely prescribed. PPI-induced diarrhoea and hypomagnesaemia are well-documented in literature. Hypomagnesaemia is well-known to cause functional hypoparathyroidism. We describe a patient who had transient profound hypoparathyroidism which improved on discontinuing PPI and normalising severe hypomagnesaemia.A 72-year-old male, who was on oral anti-diabetic medications, calcium/vitamin D3 supplements and PPI, presented wit...

Case report: A 41-year-old lady, previously diagnosed with Graves’ disease, had been treated with 12 months carbimazole in a standard block and replace regimen. The hyperthyroidism relapsed following treatment withdrawal so she was treated definitively with radio-iodine therapy, remaining well for 5 years, without hypothyroidism. The patient commenced the lighter life diet due to weight gain and subsequently presented with weight loss of a stone and atrial fibrillation (A...