Endocrine Abstracts

The search for eternal youth has created a market for treatments that might affect the process of aging, and testosterone (T) is one of the hormones that have been in focus. It is well accepted that T levels decline with increasing age, although the individual variation is large. Male hypogonadism is characterised by a low serum T level in combination with a diversity of symptoms and signs such as reduced libido and vitality, decreased muscle mass, increased fat mass and depre...

Objective: In acromegaly, high GH/IGF1 levels are associated with abnormal glucose metabolism. Treatment with somatostatin analogues (SSAs) reduces the GH and IFG-1 levels. However, SSAs may worsen glucose homeostasis despite this, due to concomitant inhibition of insulin secretion. We studied the possible association between biochemical cure and glucose homeostasis in de novo patients with acromegaly.Design: Post hoc analysis from a ra...

Objective: Early postoperative results for the Preoperative Octreotide Treatment of Acromegaly (POTA) study has been published, and like later randomized studies we demonstrated a beneficial effect of presurgical treatment with somatostatin analogues (SSA) in GH-secreting macroadenomas when evaluated 3–4 months postoperatively. However, concerns about a potential lingering effect of SSA and thereby potential false positive results have been raised. The objective of this s...

Objective: The aim of this study was to determine genetic, anthropometric and metabolic features in an unselected population of adult Norwegian patients with classical 21-hydroxylase deficiency (21OHD).Patients,Methods, and design: Sixty-four 21OHD-patients participated (23 men, 41 women; mean age 40.3 (range 19–72) in a cross-sectional study including DNA sequencing of the CYP21A1P-CYP21A2 locus, anthropometric measurements i...

Background: In many acromegalics neurosurgery is unable to control GH secretion while it may harm the normal pituitary.Objective: To investigate the effect of pre-treatment with octreotide on surgical outcome in acromegaly.Methods: Previously untreated acromegalics were randomised directly to surgery or octreotide for six month before transsphenoidal surgery. Three months postoperatively patients underwent OGTT and Insulin Toleranc...

Background: Increased frequencies of adrenal tumours and testicular adrenal rest tumours (TART) have been reported in congenital adrenal hyperplasia (CAH).Objective: To investigate the frequency of adrenal abnormalities and TART in an unselected adult population of CAH due to 21-hydroxylase deficiency (21-OH) and whether adrenal and testicular pathology correlate with disease categories, current hormone levels and treatment.Patient...

Primary hyperparathyroidism (P-HPT) is one of the most common of all endocrine disorders. 80 to 85% of cases are due to parathyroid adenomas while hyperplasia accounts for 10% to 15% and carcinoma less than 1%, of cases.1 Its very rare for parathyroid adenoma to present with clinically severe hypercalcaemia or a ‘parathyroid crisis’. There are some existing case reports.2,3 We report a case of a 67 year old woman who presented with severe irrita...