Endocrine Abstracts

There have been remarkable recent advances in bringing osteoporosis to public attention, in understanding its pathogenesis, and in improving its diagnosis and treatment.The challenges in the next decade will include the problem of delivering the benefits of this knowledge to as many patients as possible in an efficient and cost-effective manner.Up until now, all the major drugs used to prevent or treat osteoporosis are inhibitors...

Parathyroid hormone (PTH) is a novel treatment for osteoporosis, that stimulates bone formation and turnover, unlike current treatments that are antiresorptive in their actions. Both the entire molecule (1-84hPTH) and the amino-terminus of the molecule (1-34hPTH) are being studied in clinical trials. In 8 recent clinical trials (two involving males with osteoporosis) PTH has been shown to produce larger increments in vertebral bone mass than any currently available agent. In s...

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