Searchable abstracts of presentations at key conferences in endocrinology
Endocrine Abstracts (2007) 14 P103

ECE2007 Poster Presentations (1) (659 abstracts)

Prognostic value of anti-thyroperoxidase antibodies in high malignancy degree breast cancer

Emilio Fiore 1 , Claudio Giani 1 , Elisa Giustarini 1 , Ilaria Muller 1 , Claudia Mammoli 1 , Daniela Campani 3 , Manuela Roncella 2 , Loredana Fustaino 2 & Aldo Pinchera 1

1Department of Endocrinology and Metabolism, Pisa, Italy; 2Department of Surgery, Unit of Senology, Pisa, Italy; 3Department Pathology, Pisa, Italy.

A high incidence of serum anti thyro-peroxidase antibodies (TPOAb) has been found in breast cancer (BC). Aim of this study was to evaluate the predictive value of TPOAb in BC. The study group included 47 women submitted to mastectomy for high malignancy degree BC (tumor size >5 cm and/or n° lymph-nodes >3), followed for 5 years. No patient had distant metastases. All were evaluated for thyroid disorders after breast surgery and before any anti-tumoral adjuvant therapy. Thirty-one out of 47 (65.9%) patients were alive 5 years after BC diagnosis (survivors group: SG), 16/47 (34.1%) were dead during follow-up (deaths group: DG), (mean age 53.1±10.9 yrs and 53.3±8.5 yrs, respectively) (p NS).

Estrogen Receptor (ER) was measured in 43/47 (91.5%) BC speciments. ER was detected (ER+) in 19/30 (63.0%) patients in SG and 3/13 (23.1%) in DG (P=0.01, x2 5.9). Five year mortality in ER- BC was 10/21 (47.6%), and in ER+BC was 3/22 (13.6%) (P=0.008). The overall prevalence of TPOAb was 15/47 (31.9%); 14/31 (45.1%) patients in SG and 1/16 (6.2%) in DG were TPOAb+ (P=0.008). Five years mortality was 15/32 (46.9%) in TPOAb- and 1/15 (6.7%) in TPOAb + (P=0.01). TPOAb were detected in 8/21 (38.1%) ER- patients and in 7/22 (31.8%) ER+; no relation was found between ER expression and TPOAb positivity (x2 0.2; p 0.7). Age at diagnosis was not significantly related to five years survival (O.R. 0.98; 95%C.I. 0.92–1.04; P=0.6). Absence of ER expression (O.R. 6.54; 95%C.I. 1.70–25.21; P=0.006) and absence of TPOAb (O.R. 9.37; 95%C.I. 1.21–72.67; P=0.03) were related to a higher mortality rate. RE+ and TPOAb+ are positive prognostic parameters in BC and the absence of any relationship between them seems to propose an independent role on the prognosis of BC patients.

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