Searchable abstracts of presentations at key conferences in endocrinology
Endocrine Abstracts (2007) 14 P14

ECE2007 Poster Presentations (1) (659 abstracts)

Role of growth hormone/insulin like growth factor 1 system in the remodelling process of the right ventricle in top levels rowers

Giovanni Vitale 1 , Maurizio Galderisi 2 , Annamaria Colao 3 , Pasquale Innelli 2 , Germano Guerra 4 , Ermelinda Guerra 3 , Frank Lloyd Dini 5 , Antonio Soscia 4 , Oreste de Divitiis 2 & Gaetano Lombardi 3

1Chair of Endocrinology, Faculty of Medicine – University of Milan, Istituto Auxologico Italiano, Milan, Italy; 2Cardioangiology and CCU Division, Department of Clinical and Experimental Medicine, University of Naples Federico II, Naples, Italy; 3Department of Molecular and Clinical Endocrinology & Oncology, University of Naples Federico II, Naples, Italy; 4Department of Biomorphological and Functional Sciences, University of Naples Federico II, Naples, Italy; 5Cardiovascular Diseases Unit 2, Ospedale Santa Chiara, Pisa, Italy.

The intensive physical activity is often associated with cardiac changes, particularly involving the right ventricular (RV) chamber. However, the molecular mechanisms involved in the RV physiologic adaptation to long-term training are not completely understood. In the present study we investigated the role of the growth hormone/insulin like growth factor 1 (GH/IGF-1) axis in the RV remodeling of athletes.

Nineteen male top levels rowers and 19 age-matched healthy sedentary male controls underwent blood determination of fasting serum GH, IGF-1, IGF binding protein 3 (IGFBP-3) and acid-labile subunit levels and standard Doppler echocardiography combined with pulsed Tissue Doppler of RV tricuspid annulus. Myocardial pre-systolic (PSm), systolic (Sm), early diastolic (Em) and atrial (Am) velocities as well as myocardial time intervals adjusted for heart rate were calculated.

Rowers had serum IGF-1 levels (P<0.05), RV internal chamber size (P<0.05) and RV wall thickness (P<0.0001) significantly higher than controls. Additionally, rowers had improved RV systolic (higher tricuspid annular systolic excursion, higher PSm and Sm velocities; lower myocardial pre-contraction time) and diastolic function (lower A velocity, shorter deceleration time, isovolumic relaxation time and myocardial relaxation time; higher E/A ratio, Em and Em/Am ratio) compared to controls. In the rowers, IGF-1 was associated with PSm velocity (r=0.55, P=0.01) and myocardial pre-contraction time (r=−0.57, P=0.01), GH with pre-ejection period (r=−0.50, P<0.05) and Em (r=0.47, P<0.05). These associations remained significant after adjusting for age, heart rate and body surface area.

In conclusion, this study shows for the first time that the GH/IGF-1 axis is responsible for the RV functional remodeling in high-top rowers, improving mainly the systolic activity. This effect seems to be primarily modulated by the IGF-1 overproduction, as a physiological adaptation to prolonged training.

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