The aim of the study was to investigate insulin resistance, dyslipidemia and atherogenic factors influencing HDL functions in symple obesity (SO) and obesity with acanthosis nigricans (OAN). Althogether 37 children with obesity, 17 girls and 20 boys, 19 with SO and 18 with OAN, were included into the study. Their age was 14.2±1.8 years and BMI was 35.9±6.1 kg/m2.
Fasting glucose (FG), insulin (INS) were measured and HOMA-IR was calculated. Total cholesterol (T-C), LDL-C, HDL-C, triglycerid (Tg), apoproteins (Ap-AI and AP-B100), lipoprotein a) /Lp(a)/were measured, and paraoxonase (PON-1), arylesterase (ARYL), lecitin cholesterol acyltransferase (LCAT), cholesterol-ester transfer protein (CEPT) activities, intracellular adhesion molecule-1 (ICAM-1) and vascular adhesion molecule (VCAM) concentrations were determined.
FG was normal in all obese patients, hyperinsulinemia was detected in 27, insulin resistance in 31 cases of 37 children. Increased T-C and LDL-C in 55, increased Tg in 6 and decreased HDL-C in 9 patients were found, abnormal Ap-AI in 13, Ap-B100 in 5, Lp(a) in 11 cases were detected. Frequencies of abnormal INS, Tg and HDL-C values were higher in OAN than in SO. PON1, ARYL, LCAT and CEPT activities as well as ICAM-1 and VICAM-1 did not differ. ICAM-1 levels were higher in patients with low HDL-C than in cases with normal HDL-C, and a significant negative correlation was found between PON-1 and ICAM-1.
These results demonstrate that insulin resistance and atherogenic dyslipidemia are more frequent in OAN than SO, and they also suggest that atherogenic dyslipidemia in childhood obesity has a complex influence to the parameters related to HDL function.
03 - 07 May 2008
European Society of Endocrinology