ISSN 1470-3947 (print) | ISSN 1479-6848 (online)

Endocrine Abstracts (2008) 16 P557

Analysis of the central glucocorticoid feedback in patients with obesity, diabetes, and depression

Marie Greiling1, Christian Hubold1, Matthias Conrad2, Johanna Kühn1, Bernd Fischer2, Hendrik Lehnert1 & Achim Peters1

1Department of Internal Medicine I, University of Luebeck, Luebeck, Germany; 2Institute for Mathematics, University of Luebeck, Luebeck, Germany.

Obesity, diabetes, and depression are associated with distinct neuroendocrine changes influencing the regulation of the hypothalamus pituitary adrenal (HPA) system. Up to now it was not possible to examine the central glucocorticoid feedback in humans to verify results of animal experiments in relating disease models. With the help of a recently developed computational approach we were enabled to address this question to patients with obesity, diabetes, or depression.

In order to identify the glucocorticoid feedback and to analyse the kinetics of corticotropin and cortisol we established a system of differential equations. A corticotropin releasing hormone test was applied to generate the data for the analyses.

We found that subjects with obesity, depression, type 1 diabetes, or insulin treated type 2 diabetes have specific changes of central glucocorticoid feedback parameters. These changes of feedback parameters indicate an altered setpoint regulation of the HPA system in humans with psychiatric and metabolic diseases.

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