Obesity, diabetes, and depression are associated with distinct neuroendocrine changes influencing the regulation of the hypothalamus pituitary adrenal (HPA) system. Up to now it was not possible to examine the central glucocorticoid feedback in humans to verify results of animal experiments in relating disease models. With the help of a recently developed computational approach we were enabled to address this question to patients with obesity, diabetes, or depression.
In order to identify the glucocorticoid feedback and to analyse the kinetics of corticotropin and cortisol we established a system of differential equations. A corticotropin releasing hormone test was applied to generate the data for the analyses.
We found that subjects with obesity, depression, type 1 diabetes, or insulin treated type 2 diabetes have specific changes of central glucocorticoid feedback parameters. These changes of feedback parameters indicate an altered setpoint regulation of the HPA system in humans with psychiatric and metabolic diseases.
03 - 07 May 2008
European Society of Endocrinology