ECE2008 Poster Presentations Obesity (94 abstracts)
Relation of high-sensitive C-reactive protein and metabolic risk factors in overweight and obese women
Faruk Kutluturk 1 , Taner Bayraktaroglu 2 , Adil Azezli 3 & Yusuf Orhan 3
1Gaziosmanpasa Universitiy, Tokat, Turkey; 2Zonguldak Karaelmas University, Zonguldak, Turkey; 3Istanbul University, Istanbul, Turkey.
Introduction: Elevated high-sensitive c-reactive protein (hs-CRP) in association with hyperinsulinemia, obesity, insulin resistance and high blood pressure are significant risk factors for cardiovascular diseases. The aim of this study is to evaluated the correlations between serum hs-CRP concentration and metabolic risk factors in overweight and obese women.
Methods: Overweight (BMI>25 kg/m2) and obese (BMI>30 kg/m2) 755 women were enrolled into the study. The patients were divided into two groups according to serum hs-CRP concentrations. The mean serum hs-CRP concentration was 3.4 mg/dl. Group I (n=371) consist of serum hs-CRP ≤3.4 mg/dl and, group II (n=384) consist of serum hs-CRP ≥3.4 mg/dl. The groups were compared for metabolic risk markers regards of cardiovascular disease.
Results: The mean serum hs-CRP concentration was 3.4 mg/dl. Weight, body mass index (BMI) waist circumference, sagital waist, body fat, blood pressure, insulin, HOMA, WBC and uric acid were significantly high in Group II compared to Group I (P<0.05) there was no difference for glucose, cholesterol, triglyceride, HDL, LDL, kreatinin, ferritin between the groups.
Conclusion: Here in this study, we defined the correlation between increment of serum hs-CRP concentrations and metabolic risk markers regards of cardiovascular risk. These data suggest that elevated plasma hs-CRP levels might be associated with CVD risk factors in overweight and obese women.
| Parameter | Group 1 (n=371) | Group 2 (n=384) | t value |
| Age (years) | 41.50±11.71 | 42.11±11.82 | NS |
| Weight (kg) | 86.71±14.37 | 98.09±18.07 | <0.001 |
| BMI (kg/m2) | 34.45±5.67 | 39.66±7.19 | <0.001 |
| Uric acid (mg/dl) | 4.22±1.06 | 4.61±1.08 | <0.001 |
| Systolic BP (mmHg) | 127.43±22.34 | 132.53±21.94 | 0.002 |
| Diastolic BP (mmHg) | 83.44±35.09 | 85.97±35.11 | 0.043 |
| Glucose (mg/dl) | 95.85±29.64 | 97.27±24.47 | NS |
| Insulin (uIU/ml) | 12.19±10.30 | 15.21±12.38 | 0.001 |
| HOMA (log) | 3.18±4.92 | 3.74±3.39 | <0.001 |
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Endocrine Abstracts
ISSN 1470-3947 (print) | ISSN 1479-6848 (online)
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