Introduction: Elevated high-sensitive c-reactive protein (hs-CRP) in association with hyperinsulinemia, obesity, insulin resistance and high blood pressure are significant risk factors for cardiovascular diseases. The aim of this study is to evaluated the correlations between serum hs-CRP concentration and metabolic risk factors in overweight and obese women.
Methods: Overweight (BMI>25 kg/m2) and obese (BMI>30 kg/m2) 755 women were enrolled into the study. The patients were divided into two groups according to serum hs-CRP concentrations. The mean serum hs-CRP concentration was 3.4 mg/dl. Group I (n=371) consist of serum hs-CRP ≤3.4 mg/dl and, group II (n=384) consist of serum hs-CRP ≥3.4 mg/dl. The groups were compared for metabolic risk markers regards of cardiovascular disease.
Results: The mean serum hs-CRP concentration was 3.4 mg/dl. Weight, body mass index (BMI) waist circumference, sagital waist, body fat, blood pressure, insulin, HOMA, WBC and uric acid were significantly high in Group II compared to Group I (P<0.05) there was no difference for glucose, cholesterol, triglyceride, HDL, LDL, kreatinin, ferritin between the groups.
Conclusion: Here in this study, we defined the correlation between increment of serum hs-CRP concentrations and metabolic risk markers regards of cardiovascular risk. These data suggest that elevated plasma hs-CRP levels might be associated with CVD risk factors in overweight and obese women.
|Parameter||Group 1 (n=371)||Group 2 (n=384)||t value|
|Uric acid (mg/dl)||4.22±1.06||4.61±1.08||<0.001|
|Systolic BP (mmHg)||127.43±22.34||132.53±21.94||0.002|
|Diastolic BP (mmHg)||83.44±35.09||85.97±35.11||0.043|
03 - 07 May 2008
European Society of Endocrinology