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Endocrine Abstracts (2014) 35 P1048 | DOI: 10.1530/endoabs.35.P1048


1School of Medicine Section of Endocrinology and Metabolism, Marmara University, Istanbul, Turkey; 2Malatya State Hospital, Malatya, Turkey; 3Ondokuz Mayis University, Samsun, Turkey; 4School of Medicine, Abant Izzet Baysal University, Duzce, Turkey; 5Medical School, Celal Bayar University, Manisa, Turkey; 6Medical School, Inonu University, Malatya, Turkey; 7Giresun State Hospital, Giresun, Turkey; 8Medical School, Namik Kemal University, Tekirdag, Turkey; 9School of Medicine, Ege University, Izmir, Turkey; 10Fatih Sultan Mehmet Hospital, Istanbul, Turkey; 11Uskudar State Hospital, Istanbul, Turkey; 12Kilis State Hospital, Gaziantep, Turkey.

Non adherence to medication schedules by patients with chronic illnesses has long been recognized as a problem. The aim of this study is to evaluate levothyroxine (L-T4) compliance, daily dosage and TSH levels under treatment in primary hypothyroid patients.

We included 1636 primary hypothyroid patients over 1 year under L-T4 (F/M: 1469/167, 46±13 years of age) included from 11 tertiary health care centres around Turkey. A survey covers on disease duration, daily dosage, adherence to L-T4 recommendations were performed.

Duration of the L-T4 treatment was 5.9±6.7 years, L-T4 dosage was 96.6 μg/day and 1.3 μg/kg per day, TSH level was 4.8 mIU/l 32.3% of patients were not compliant to the treatment. Compliance rates differs between the centres with a maximum 84% and minimum 55%.

Noncompliant patients have higher TSH (6.9±16 vs 3.8±0.9 mIU/l, P=0.01) and shorter duration of disease (5.8±6.9 vs 6.0±6.5 years, P<0.05) compared to compliant patients. There was no difference of, dosage of L-T4 between compliant and non-compliant patients.

Our results suggest that non-compliance of L-T4 treatment is associated with subclinical hypothyroidism in our study group. Approximately 67.7% of patients follow treatment recommendations but compliance rates differs between the centre’s. The physician–patient relationship seems to have key role in adherence to levothyroxine regimen.

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