Searchable abstracts of presentations at key conferences in endocrinology
Endocrine Abstracts (2015) 37 EP641 | DOI: 10.1530/endoabs.37.EP641

ECE2015 Eposter Presentations Obesity and cardiovascular endocrinology (108 abstracts)

Body composition in HIV-infected patients under combined antiretroviral therapy over 5 years

Inês Grenha 1, , Joana Oliveira 1, , Eva Lau 1, , Romana Vieira 2, , Rosário Serrão 3, , António Sarmento 3, , Davide Carvalho 1, & Paula Freitas 1,

1Endocrinology, Diabetes and Metabolism Department, Centro Hospitalar São João, Porto, Portugal; 2Reumathology Department, Centro Hospitalar São João, Porto, Portugal; 3nfectious Diseases Department, Centro Hospitar São João, Porto, Portugal; 4Faculty of Medicine of University of Porto, Porto, Portugal

Introduction: HIV infection and combined antiretroviral therapy (cART) have been associated with lipodistrophy and changes in body composition. However, there are few studies on body composition evolution of HIV-infected patients, under cART.

Aims: To evaluate the evolution of body composition in HIV-1 infected patients under cART over 5 years.

Methods: Retrospective, observational study in a cohort of HIV-infected patients on cART. Evaluation of clinical data and body composition (total fat mass, upper-limbs fat mass, lower-limbs fat mass, trunk fat mass and fat-free mass) by DXA (whole-body dual-energy X-ray absorptiometry).

Results: A total of 257 patients were evaluated, with a mean age of 45.98 (11.51) years. 63% were males. The median duration of HIV infection was 7.92 (IQR: 3.90) years and the median duration of cART was 6.61 (IQR: 3.9) years. Males had a baseline mean BMI of 24.37 (22.17–26.91) Kg/m2. Over the five years, there was a significant increase in their % of upper limbs, lower limbs, trunk and total fat mass. At baseline, women had a mean BMI of 25.33 (21.92–29.18) Kg/m2. Women showed significant decrease in their % of lower limbs fat mass and an increase in % of trunk fat mass; % of total fat mass increased during the first two years and decreased since then. No differences were found regarding fat mass ratio, in both genders. During the five years of follow-up period, man showed a decrease of total fat-free mass and increase of upper-limbs fat-free mass; significant changes were also observed in lower-limbs and trunk fat-free mass distribution. Women also showed significant changes in total, lower-limbs, upper-limbs and trunk fat-free mass during follow-up.

Conclusion: Over the 5 years, there were significant changes in body composition, in HIV-infected patients on cART. Different from women, men showed a sustained increase in % of fat mass of all segments evaluated.

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