ECE2015 Guided Posters Calcium, Vitamin D and Bone (1) (9 abstracts)
The evaluation of central corneal and retinal thickness and intraocular pressure in patients with primary hyperparathyroidism
Husniye Baser 1 , Fatma Neslihan Cuhaci 2 , Oya Topaloglu 2 , Fatma Yulek 3 , Nagihan Ugurlu 3 , Reyhan Ersoy 2 , Nurullah Cagil 3 & Bekir Cakir 2
1Department of Endocrinology and Metabolism, Ataturk Education and Research Hospital, Ankara, Turkey; 2Department of Endocrinology and Metabolism, Faculty of Medicine, Yildirim Beyazit University, Ankara, Turkey; 3Department of Ophthalmology, Ataturk Education and Research Hospital, Ankara, Turkey.
Introduction: Ocular changes are common in various endocrine disorders. However, there are only few studies reporting ocular changes in patients with primary hyperparathyroidism (PHPT). Here, we examined central corneal thickness (CCT) and retinal thickness (RT), intraocular pressure (IOP) and their relationships with serum intact parathyroid hormone (iPTH), calcium (Ca), and phosphorus levels in PHPT patients.
Methods: Thirty-seven patients with PHPT were included and compared with age- and sex-matched 43 controls. CCT, RT, and IOP were measured.
Results: There was no statistically significant difference in mean right and left RT between two groups (P=0.730 and P=0.530 respectively). Right CCT and IOP were significantly higher than controls (P=0.024 and P=0.038 respectively). However, no significant difference was found between groups concerning left CCT and IOP (P=0.415 and P=0.070 respectively). A negative correlation was observed between right CCT, and serum phosphorus and 24-h urine phosphorus levels (r=−0.391, P=0.017 and r=−0.393, P=0.021 respectively). Additionally, right IOP was negatively correlated with 24-h urine calcium levels (r=−0.331, P=0.049). Left CCT was negatively correlated with 24-h urine phosphorus levels (r=−0.348, P=0.044). Furthermore, negative correlation was found between left IOP and 24-h urine calcium levels (r=−0.396, P=0.017). No significant correlation was found between iPTH levels and right CCT, right RT, right IOP, left CCT, left RT, and left IOP levels (P>0.05 for all parameters). Also, serum Ca levels were not significantly correlated with right CCT, right RT, right IOP, left CCT, left RT, and left IOP levels (P>0.05 for all parameters).
Conclusion: In the literature, data about ocular diseases and PHPT are rare. In this study, we observed right CCT and IOP values of patients with PHPT were significantly higher than controls. We consider that the identification of ocular aspects of PHPT is significant, and further studies related to the condition are required.
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Endocrine Abstracts
ISSN 1470-3947 (print) | ISSN 1479-6848 (online)
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