Endocrine Abstracts (2015) 38 P296 | DOI: 10.1530/endoabs.38.P296

Hyperuricaemia and peripheral arterial disease in patients with diabetes mellitus

Anthonia Ogbera & Victor Osagie

Lagos State University College Of Medicine, Lagos, Nigeria.

Introduction: The objective of this Report is to evaluate for a possible association between serum uric acid levels and PAD in persons with diabetes mellitus.

Methods: This was a cross sectional Study carried out in 232 DM patients, Anthropometric indices and ankle brachial pressure indices were documented. Biochemical analyses were carried out for lipid parameters, glycosylated haemoglobin and uric acid.

Results: The mean age and age range of the study subjects were 61.1 (10.6) years and 28–87 years respectively. A total of 92 patients (39.7%) had PAD (ABI of ≤0.9). Hyperuricaemia was found to be a possible predictor of PAD (OR 0.51, 95% CI 0.27–0.98, P=0.004). There was however a positive and significant correlation between duration of DM (r=+0; 14, P=0.02), glycosylated haemoglobin (r=+0.13, P=0.04) and ankle brachial pressure indices.

Conclusion: Elevated uric acid level is a potential risk factor for PAD in persons with DM.

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