Searchable abstracts of presentations at key conferences in endocrinology
Endocrine Abstracts (2015) 38 P297 | DOI: 10.1530/endoabs.38.P297

SFEBES2015 Poster Presentations Obesity, diabetes, metabolism and cardiovascular (108 abstracts)

Similia similibus curantur: using DPP-IV inhibitor to treat reactive hypoglycaemia

Marisa Clemente 1 & B Moulinath 1,

1Wirral University Teaching Hospitals NHS Foundation Trust, Wirral, UK; 2Manchester University, Manchester, UK.

Introduction: Reactive hypoglycaemia (RH) is a complex problem, with no definite treatment apart from lifestyle changes.

Methods: We used Sitagliptin in two patients with RH, who had tried lifestyle changes for at least 2 years but without much effect. A gentleman with initial BMI of 31.4 kg/m2 and another lady of BMI 24.1 kg/m2 was treated with Sitagliptin 100 and 50 mg daily, in view of their weight and thereby volume of distribution, with informed consent about this unlicensed indication.

Results: Within a month, the incidence of hypoglycaemia had gone down to none and in 6 months’ time, the gentleman had lost 11.1 kg, while the lady’s weight remained stable. OGTT performed before and 6 months after treatment with Sitagliptin taken in the morning of the test showed reduction in glycaemic excursions and delay in the onset of hypoglycaemia in both these patients.

Conclusion: DPP-IV inhibitors by their property of glucose mediated insulin release and slowing of gastrointestinal motion, can be useful adjuncts to patients with RH. Further studies on larger number of patients need to be done.


Volume 38

Society for Endocrinology BES 2015

Edinburgh, UK
02 Nov 2015 - 04 Nov 2015

Society for Endocrinology 

Browse other volumes

Article tools

My recent searches

No recent searches.