Searchable abstracts of presentations at key conferences in endocrinology
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18th European Congress of Endocrinology

Eposter Presentations

Steroid metabolism + action

ea0041ep953 | Steroid metabolism + action | ECE2016

Sex hormones and sleep in men and women from the general population: a cross-sectional observational study

Kische Hanna , Ewert Ralf , Fietze Ingo , Gross Stefan , Wallaschofski Henri , Volzke Henry , Dorr Marcus , Nauck Matthias , Obst Anne , Stubbe Beate , Penzel Thomas , Haring Robin

Introduction: To date, associations between sex hormones and sleep were mainly investigated in small and selected patient-based samples. Thus, we examined a comprehensive panel of mass spectrometry-measured sex hormones and various sleep characteristics in a population-based sample of healthy men and women from the general population.Methods: We used data from 204 men and 213 women of the cross-sectional Study of Health in Pomerania TREND, who underwent ...

ea0041ep954 | Steroid metabolism + action | ECE2016

First generation testosterone assays are influenced by sex hormone binding globulin concentrations as evidenced during oral contraceptive use and pregnancy

Heijboer Annemieke , Savelkoul Edo , Kruit Adrian , Endert Erik , Blankenstein Marinus

Introduction: The quality of testosterone assays has been a matter of debate for several years. Known limitations of testosterone immunoassays are the cross-reactivity with other steroids and a high variation in the low concentration range. We hypothesized that one of the additional limitations of testosterone immunoassays is an ineffective displacement of testosterone from its binding protein.Methods: Thirty samples from women not using oral contracepti...

ea0041ep955 | Steroid metabolism + action | ECE2016

Testosterone therapy in female-to-male transsexuals: effects on gonadotropins, prolactin, gonadal steroids and menstrual cycle

Martin Francisco Javier Martinez , Arroyo Sara Quintana , Calero Carmen Acosta , Leon Claudia Arnas , Suarez Ana Delia Santana

Introduction and objectives: Testosterone therapy (TT) in female-to-male transsexuals (FMT) usually causes cessation of menses within the first few months. However the changes in the hormonal profile are not well known. We set out to analyze the hormonal changes and menstrual evolution in a cohort of FMT who began TT.Methodology: Retrospective observational study with no control group in a cohort of 34 FMT patients who started TT following a standard pro...

ea0041ep956 | Steroid metabolism + action | ECE2016

An estrogen receptor signaling pathway is involved in 3,3′-diindolylmethane-induced inhibition of cell migration of MCF-7 breast cancer caused by triclosan via the regulation of epithelial- mesenchymal transition

Lee Geum-A , Choi Kyung-Chul , Hwang Kyung-A

Triclosan (TCS) is an endocrine-disrupting chemical and has a potential to increase progression of hormone responsive cancers as does 17β-estradiol (E2). 3,3′-diindolylmethane (DIM), a phytoestrogen, has been known to have anticancer activity. In this study, we examined the anti-proliferative and anti-epithelial-mesenchymal transition (EMT) effects of DIM on TCS or E2-induced EMT of MCF-7 breast cancer cells, which express estrogen receptors (E...

ea0041ep957 | Steroid metabolism + action | ECE2016

Similarity and differences of maximal and sub-maximal endurance exercise in increase the serum testosterone and DHT concentrations in healthy males

Sgro Paolo , Sansone Massimiliano , Romanelli Francesco , Lenzi Andrea , Bianchini Serena , Luigi Luigi Di

Introduction: Physical exercise exerts several effects on endocrinological homeostasis and, in particular, sprint exercise elicits the largest testosterone response per unit of work, while in response to prolonged endurance exercise testosterone levels will typically decline. In contrast to a large amount of paper about the modification of testosterone during physical exercise few study evaluated how DHT was influenced by a single bout of aerobic exercise.<p class="abstext...

ea0041ep958 | Steroid metabolism + action | ECE2016

Resting state functional connectivity is affected by testosterone treatment in female-to-male transgender persons

Nota Nienke , Burke Sarah , den Heijer Martin , Soleman Remi , Lambalk Cornelis , Veltman Dick , Cohen-Kettenis Peggy , Kreukels Baudewijntje

Background: Several resting state networks have been described in literature. Today, it is still unclear whether these networks are stable or can be influenced by sex hormones. Transgender persons offer a unique opportunity to study these hormonal influences.Objective: To examine the effects of cross-sex hormone treatment in transgender persons on two resting state networks involved in cognition and emotion, the default mode network and executive network...

ea0041ep959 | Steroid metabolism + action | ECE2016

Effect of estradiol on the development of hypoxic pulmonary hypertension (O2=13%, 10%, 6%) and blood hematocrit in the female ovariectomized rats

Medvedeva Natalia , Medvedev Oleg

Objective: The role of sex in pulmonary hypertension (PAH) is not fully known. The majority of animal studies have suggested a protective role of female sex hormone in PAH. But women of various ages are more subjected to PAH compared with male. The aim of current research was to test the hypothesis that the level of oxygen in the inspired air can influence on the effect of estradiol on the development of experimental PAH in female rats.Methods and design...

ea0041ep960 | Steroid metabolism + action | ECE2016

17β-estradiol or triclosan-induced epithelial-mesenchymal transition and migration of MCF-7 breast cancer cells were reversed by kaempferol, a phytoestrogen

Lee Geum-A , Hwang Kyung-A , Choi Kyung-Chul

As a phytoestrogen, kaempferol plays a chemopreventive role inhibiting cancer formation and progression. In this study, chemopreventive activity of kaempferol was examined by measuring its effect on growth, epithelial-mesenchymal transition (EMT), and migration of MCF-7 breast cancer cells increased by 17β-estradiol (E2, a positive control) or triclosan (TCS), an endocrine-disrupting chemical (EDC). As an EDC, TCS is known to interfere estrogen receptor (ER) dependent pat...

ea0041ep961 | Steroid metabolism + action | ECE2016

Increase in insuline-like growh factor levels during cross-sex hormone treatment in transgender persons

Nota Nienke , Dekker Marieke , Klaver Maartje , Wiepjes Chantal , Heijboer Annemieke , den Heijer Martin

Background: Sex steroids probably stimulate growth-hormone secretion during puberty, which in turn contributes to the development of gender specific body characteristics. Hypothetically, adequate growth hormone levels in transgender persons are also important to achieve the best therapeutic results. The influence of cross-sex hormone treatment (CHT) at growth-hormone production in adult transgender persons is not yet elucidated.Objective: To investigate ...

ea0041ep962 | Steroid metabolism + action | ECE2016

Effects of sex steroid hormone on regulation and localization of the calcium related genes in rat esophagus

Kim Kipoong , Ai Kang Song , Ahn Changhwan , Nam Tran Dinh , Jeung Eui-Bae

Calcium ion is important for physiological functions in all tissues and organs, and is essential for many vital functions. Calcium in lumen is absorbed to cytosol, and Calbindin-D9k binds calcium. It can remove calcium to extracellular through PMCA1 and NCX1. However, in the rat esophagus, the calcium related gene regulations and localizations were not well documented. We evaluated calcium related genes including Calbindin-D9k, PMCA1, and NCX1. Immature rats were daily treated...

ea0041ep963 | Steroid metabolism + action | ECE2016

How does energy intake influence the levels of certain steroids?

Jandikova Hana , Duskova Michaela , Racz Beata , Pospisilova Hana , Sramkova Monika , Hill Martin , Vondra Karel , Starka Luboslav

Introduction: The influence of steroid hormones on food intake is well described. However, there are only a few studies on the effect of food intake on steroid levels.Methods: The study involved eight non-smoker women (average age 29.48±2.99 years; average BMI 21.3±1.3 kg/m2); they did not use any kind of medication affecting steroidogenesis. We analysed the influence of four various stimuli on the levels of steroid hormones and mela...

ea0041ep964 | Steroid metabolism + action | ECE2016

Endocrinological approach of individuals with gender dysphoria (transsexuality): experience of a large center

Martins Diana , Bastos Margarida , Baptista Carla , Fonseca Ligia , Santos Graca , Carvalho Giselda , Rolo Francisco , Pinheiro Susana , Guelho Daniela , Vicente Nuno , Cardoso Luis , Oliveira Diana , Lages Adriana , Ventura Mara , Carrilho Francisco

Introduction:: Gender dysphoria (GD) is featured by significant difference between the individual’s expressed gender and the gender others would assign him or her, with marked distress in social and occupational functionality, according to DSM-V classification. We report the experience in the clinical evaluation and the results of hormonal therapy and sex reassignment surgery in a hospital center.Methods:: It was conducted a retrospective analysis o...