Endocrine Abstracts

Introduction: Although underlying mechanisms are largely unknown, bone metabolism is regulated by specific microRNAs and changes in their expression are associated with metabolic bone disorders. Exercise is a determinant of bone metabolism; however, different training protocols differently affect bone. Little is known about the effects of exercise on bone-specific miRNA expression.We studied the effect of a 8-week high-intensity training protocol on circ...

Introduction: Hormonal replacement therapy (HRT) increases bone mineral density (BMD). Controversy exists regarding residual effect after withdrawal. We aimed to explore the effect of HRT and HRT withdrawal on: i) BMD and bone microarchitecture assessed by trabecular bone score (TBS); ii) fat (FMI), lean (LMI) and appendicular lean (ALMI) mass indexes.Methods: The OsteoLaus Cohort assessed 1500 women (50–80 years) for BMD, TBS, total energy expendit...

Ageing is associated with sarcopenia, osteoporosis and an increased risk of falling, which together contribute to increased fracture risk. There are few data describing the associations between functional measures of muscle and bone during ageing. Therefore, the aim of this study was to examine in ageing men associations between measures of lower-limb muscle strength and age and then to investigate the relationships with tibial bone outcomes.Men (n</...

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Objective: Osteoporosis is a typical long-term complication after solid organ transplantation. Patients after simultaneous pancreas kidney transplantation (SPK) are at a very high risk due to preceding renal osteopathy and diabetic status. To determine the best preventive strategy we analysed the bone metabolism at the point of the pretransplant examination.Design and methods: In years 2011–2014 the number of 112 patients with type 1 diabetes (69 me...

Background: Survivors with Fontan circulation suffer from chronic systemic hypoperfusion resulting in end-organ injury. Little is known about the effects of these hemodynamic perturbations on bone. We hypothesized that chronic Fontan circulation (>5 years after surgery) would be associated with bone deficits.Methods: Peripheral quantitative computed tomography (pQCT) was performed on 10 Fontan patients (seven males, 11.8±1.7 years) and 11 health...

Introduction: Osteoporosis is known chronic complication of inflammatory bowel diseases (IBD). It is known that areal bone mineral density (aBMD) does not sufficiently reflect bone strength and quality. The trabecular bone score (TBS) provides an indirect measurement of bone microarchitecture, independent of aBMD.Aims and methods: The aim was to assess TBS in IBD patients with regard to disease behavior using in comparison with lumbar spine (LS) BMD. The...

Introduction: Intrauterine weeks 36–38 with rapid transplacental mineral transfer are crucial for skeletal development. Prematurity and low birthweight may therefore lead to a subnormal peak bone mass. We evaluated the influence of gestational age and low birthweight on bone mineral density (BMD) and content (BMC) in young adults born preterm with very low birthweight (VLBW) and small for gestational age (SGA) at term.Description of methods/design: ...

Introduction: Osteoporosis is a chronic and dangerous disease, as it may be silent and may express itself with a sudden catastrophic event, such as a fracture. Treatment of osteoporosis demands the use of potent pharmaceutical agents with long lasting effects. In particular, bisphosphonates, such as ibandronate, may be used. It has become evident that chronic treatment with anti-osteoporotic agents may reverse the course of the disease, patients having normal bone mineral dens...

Tumor-induced osteomalacia (TIO) is a rare acquired paraneoplastic syndrome clinically presenting with recurring fractures, muscular weakness and pain. Laboratory values of affected patients are characterized by renal phosphate wasting and hypophosphatemia caused by an overexpression of fibroblast growth factor 23 (FGF- 23), a hormone belonging to the group of phosphatonins regulating phosphate and vitamin D homeostasis. Pathologically, it is secreted especially by small (and ...