ECE2017 Eposter Presentations: Reproductive Endocrinology Female Reproduction (62 abstracts)
Serum concentrations of betatrophin and its association with indirect indices of insulin resistance and beta cell function in women with polycystic ovary syndrome
Agnieszka Adamska 1 , Agnieszka Lebkowska 1 , Malgorzata Jacewicz 1 , Anna Krentowska 1 , Justyna Hryniewicka 1 , Slawomir Wolczynski 2 , Maria Gorska 1 & Irina Kowalska 1
1Department of Endocrinology, Diabetology and Internal Medicine, Medical University of Białystok, Bialystok, Poland; 2Department of Reproduction and Gynecological Endocrinology, Medical University of Białystok, Bialystok, Poland.
The accumulated data underline the role of betatrophin in glucose homeostasis. Polycystic ovary syndrome (PCOS) is characterized by insulin resistance and high risk of developing prediabetes and diabetes. The aim of our study was to investigate the relationship of serum betatrophin concentrations with indirect indices of insulin resistance and insulin secretion in women with PCOS, comparing to the control group. The study group comprised 43 women with PCOS and 16 controls matched for BMI and age. An oral glucose tolerance test (OGTT) with estimation of serum betatrophin concentrations was performed. Insulin resistance was assessed by HOMA-IR and Matsuda index. Insulin secretion was evaluated by HOMA-B. Glucose load resulted in an increase of serum betatrophin concentrations only in the control group (P=0.02). Consequently, serum betatrophin concentrations at 120′ of OGTT were lower in women with PCOS in comparison to the control group (P=0.02). We observed a positive relationship between baseline serum betatrophin concentrations and baseline serum insulin concentrations (r=0.42, P=0.004) in PCOS group. Additionally, correlations between baseline serum betatrophin concentrations and HOMA-IR (r=0.39, P=0.008), HOMA-B (r=0.38, P=0.01) and Matsuda index (r=−0.31, P=0.004) were observed in women with PCOS. We found relationship between Δ betatrophin and serum total testosterone concentration in the entire group (r=−0.32, P=0.01). Multiple regression analysis revealed that HOMA-B (β=0.47, P=0.001) was an independent factor connected to serum betatrophin levels in women with PCOS. Serum concentrations of betatrophin is connected with insulin resistance and beta cell function and did not change after glucose load in women with PCOS.
Article tools
My recent searches
My recently viewed abstracts
Authors
Endocrine Abstracts
ISSN 1470-3947 (print) | ISSN 1479-6848 (online)
© Bioscientifica 2024 |
Privacy policy |
Cookie settings
BiosciAbstracts
Bioscientifica Abstracts is the gateway to a series of products that provide a permanent, citable record of abstracts for biomedical and life science conferences.
Find out more