Thyroid disorders and polycystic ovary syndrome (PCOS) are two of the most common endocrine disorders in general population. Autoimmune thyroid diseases are common autoimmune disorders that affect about 5% to 20% of women in childbearing age. In this study, we evaluate the comorbidity rate of euthyroid Hashimotos Thyroiditis (HT) in PCOS patients and possible influence of thyroid autoantibodies on clinical and laboratory findings of PCOS. This study includes 285 PCOS patients attending to our outpatient Endocrinology Clinic at Erzurum Region Training and Research Hospital. The control group include 32 age and body mass index matched healty women. In PCOS group 88 of 285 (%30.87) patients have euthyroid Hashimatos disease where as in control group 2 of 32 (%6.25) have disease. These findings are statistically significant (P=0.003). None of the euthyroid Hashimatos patients take L-thyroxine replacement therapy. Anti-TPO and anti-TG were significantly higher in patients with PCOS (P=0.000; P=0.01; respectively). Anti-TPO had a significantly positive correlation between PCOS presence (r=0.119; P=0.036), and clinical indicators of PCOS such as cycle time (r=0.709; P=0.000), Ferriman-Gallwey score (r=0.376; P=0.001), DHEAS (r=0.132; P=0.04), testosterone (r=0.124; P=0.043), and LH/FSH (r=0.136; P=0.025). TPO was seen to be an independent risk factor from body mass index, age and TSH in PCO patients. Anti-TPO and anti-Tg were also sensitive and spesific in diagnosing PCOS. AUC value of Anti-TPO was 0.843 (P=0.000) and Anti-Tg was 0.843 (P=0.000). In ROC analysis, TPO≥4.9 had 99.6% sensitivity and 71% specificity, anti TG ≥18 had 94.8% sensitivity and 75% specificity in predicting PCOS. In our study thyroid autoantibodies were significantly higher in patients with PCOS. We think that thyroid autoantibodies can affect the clinical and laboratory course of PCOS. We have found that the euthyroid HT may be observed at higher rates in PCOS patients, independent of the thyroid function tests.
Keywords: polycystic ovary syndrome, Hashimotos Thyroiditis, thyroid autoantibodies
20 - 23 May 2017
European Society of Endocrinology