Abstract: Nicotinamide phosphoribosyltransferase (NAMPT) overexpression was reported in many autoimmune diseases. We have also found NAMPT overexpression in leukocytes of patients with Graves orbitopathy. Therefore, we aimed to analyze NAMPT expression level in thyroid gland of patients with Graves disease with orbitopathy and without orbitopathy, and in healthy thyroid gland. We have analyzed 80 thyroid tissue samples of patients who underwent thyroidectomy. Among these, there were 41 patients with Graves disease (20 patients with orbitopathy and 21 patients without orbitopathy), and 39 samples of healthy thyroid tissue. NAMPT overexpression was found in thyroid glands of patients with Graves orbitopathy (P<0.000001). NAMPT expression in patients with Graves disease without orbitopathy was similar to healthy controls. Our results suggested that NAMPT might be involved in the inflammatory cascade in Graves orbitopathy.
20 - 23 May 2017
European Society of Endocrinology