Endocrine Abstracts (2017) 49 EP1275 | DOI: 10.1530/endoabs.49.EP1275

Nicotinamide phosphoribosyltransferase expression in thyroid glands of patients with Graves' disease

Nadia Sawicka-Gutaj1, Miroslaw Andrusiewicz2, Agata Czarnywojtek1,3, Joanna Waligorska-Stachura1, Maciej Biczysko4, Jerzy Skrobisz4, Jerzy Sowinski1 & Marek Ruchala1

1Poznan University of Medical Sciences, Department of Endocrinology, Metabolism and Internal Medicine, Poznan, Poland; 2Poznan University of Medical Sciences, Department of Cell Biology, Poznan, Poland; 3Poznan University of Medical Sciences, Department of Pharmacology, Poznan, Poland; 4Department of General Surgery and Multiple Trauma, with Division of Gastroenterological and Endocrine Surgery, Provincial Hospital, Poznan, Poland.

Abstract: Nicotinamide phosphoribosyltransferase (NAMPT) overexpression was reported in many autoimmune diseases. We have also found NAMPT overexpression in leukocytes of patients with Graves’ orbitopathy. Therefore, we aimed to analyze NAMPT expression level in thyroid gland of patients with Graves’ disease with orbitopathy and without orbitopathy, and in healthy thyroid gland. We have analyzed 80 thyroid tissue samples of patients who underwent thyroidectomy. Among these, there were 41 patients with Graves’ disease (20 patients with orbitopathy and 21 patients without orbitopathy), and 39 samples of healthy thyroid tissue. NAMPT overexpression was found in thyroid glands of patients with Graves’ orbitopathy (P<0.000001). NAMPT expression in patients with Graves’ disease without orbitopathy was similar to healthy controls. Our results suggested that NAMPT might be involved in the inflammatory cascade in Graves’ orbitopathy.

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