Introduction: Type 2 diabetes mellitus (T2DM) affects bone metabolism, but its relation with bone mineral density (BMD) remains controversial. It is also known that T2DM is associated with hypogonadism in males. Male hypogonadism can also affect BMD. Thus the aim of this study was to evaluate BMD in male patients with T2DM with and without hypogonadism.
Methods/design: Hypogonadism was defined as serum free Testosterone (fT) value <5 ng/dl or 59 ng/dl +1 major sign suggestive of androgen deficiency and eugonadism was defined as fT value >9 ng/dl. We studied 119 patients with T2DM and hypogonadism (Group H) (age: 61.2±8.2 years) and 45 patients with T2DM without hypogonadism (Group NH) (age: 58.4±10.3 years) matched for age, duration of diabetes, BMI and HbA1c. In both groups, we measured, lumbar spine (LS) BMD and total Tscore by Dual-energy X-ray absorptiometry (DEXA).
Results: Mean BMI (kg/m2) was similar in both groups (H: 30.9±5.0 vs NH: 29.6±5.9, P=0.17). Mean duration of diabetes was 9.4±8.5 years in Group H and 8.6±7.8 years in Group NH (P=0.54) and mean HbA1c was 7.8±1.9% in Group H and in Group NH 7.61±1.5%(P=0.47). BMD at LS (g/cm2) and total T-score measured by DEXA were lower in Group H compared to Group NH (0.53±0.08 vs 0.81±0.07, P=0.041) (−0.12±1.0 vs 0.78±0.72, P<0.001).
Conclusion: Male patients with T2DM and hypogonadism are found to have lower BMD compared to T2DM males without hypogonadism. Thus, in male patients with T2DM, hypogonadism is a risk factor for low BMD.
20 May 2017 - 23 May 2017