Endocrine Abstracts

Introduction: Pregnancy as a state of insulin resistance can predict diabetes development in some women, and is associated with increased risk for adverse outcome of neonate and for mother.

Aim: The aim of this study is to analyse pregnancy outcome in relation to a disorder of glucose tolerance during pregnancy.

Matherial and methods: The study included 77 healthy pregnant women in third trimester registered in Center for endocrinology CC Kragujevac that were tested, according to conducted 3 h OGTT with 100 g glucose (ADA criteria). As parameters of adverse outcomes we included: premature labor (before 37 gw., Low Apgar score (<8), neonatal malformations, respiratory complications, hypoglycemia, birth body weight >4 000 g or <2 500 g, hyperbilirubinemia

Results: The mean age of patients was 30.8±4.7 years. The frequency of risk factors for diabetes were: obesity (3.9%), hypertension (5.2%), previous gestational diabetes mellitus (23.5%), smoking (23.4%), positive family history for diabetes (27.3%). From 77 patients, 18 was with GDM (23.3%). It has been shown that the number of risk factors significantly affect the outcome of pregnancy (P<0.005, χ² test), and that the degree of disorder of glucose tolerance during pregnancy affect the outcome of pregnancy (r=0.164, χ² test). It has been shown that patients with normal glucose tolerance usually have a favorable outcome of pregnancy, and a growing number of pregnancies with an adverse outcome.

Conclusion: This study demonstrates that glucose intolerance during pregnancy predicts unfavorable adverse outcome

Keywords: glicoregulation, pregnancy outcome