ISSN 1470-3947 (print) | ISSN 1479-6848 (online)

Endocrine Abstracts (2019) 63 P848 | DOI: 10.1530/endoabs.63.P848

Synchronous tumours: Neuroendocrine Tumours and Breast cancer

Fatma Mnif, Kawthar El Arbi, Faten Hadj Kacem, Asma Zargni, Mouna Elleuch, Douha Ben Salah, Nedia Charfi, Mouna Mnif, Nabila Rekik & Mohamed Abid

Department of Endocrinology and Diabetology, UH Hedi Chaker, Sfax, Tunisia.

Introduction:: The association of breast cancer and neuroendocrine tumours, in particular pheochromocytoma, is rarely described in the literature. We report a case in a particular context.

Observation: This is a 53-year-old patient treated with 6 courses of chemotherapy for T2N3cM0 infiltrating breast carcinoma. She was admitted to our endocrinology department for exploration of a left adrenal incidentaloma, objectified in the extension assessment, measuring 53 * 55 mm with mass effect on the superior-internal rim of the left kidney. The adrenal tumour was therefore strongly suspected to be a pheochromocytoma. On clinical examination, the patient was normotensive and reported no symptoms of catecholamine secretion. The urinary and plasma normetanephrines were raised to 9.51 μmol / 24h (VN: 0.4–2.1) and 4884.2 pmol/L (VN <1070.2) respectively. Investigations for other adrenal hormones, including an overnight dexamethasone suppression test, plasma aldosterone level were all within the normal ranges. After preoperative conditioning, left adrenalectomy was performed. The surgery was followed by a pathological examination that confirmed the pheochromocytoma diagnosis.

Conclusion: The case of our patient with a combination of breast cancer and a neuroendocrine tumour is the second published case. Some pathophysiological links between these two pathologies are mentioned but the exact relationship remains unclear.

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