Endocrine Abstracts

Background: Psoriasis is a common chronic, inflammatory skin disease that may exhibit a variety of clinical manifestations. Psoriasis has also been identified as a multisystem chronic inflammatory disorder associated with multiple comorbidities. Recently has been reported a role for vitamin D in the pathogenesis of different skin diseases, including psoriasis.

Aim: The objective of this study was to measure the serum level of vitamin D in patients with psoriasis and compare it with the level in the control group.

Materials and methods: The study was conducted in the department of dermatology.100 cases were included, 50 patients clinically diagnosed with psoriasis and 50 normal people. The level of Vit D was measured with k–imunofluoresence. Normal level > 30 ng/ml = vit D sufficiency, levels 11–30 ng/ml = vit D insufficiency, levels <10 ng/ml = vit D deficiency. The testing of vitamin D was done during the fall. The characteristics of the population in the study. Psoriatic patients:60% of the patients were male and 40% were female.10% of women were black skin.10 % of men were black skin.15% of women were in menopause. The average age was 44.1 years ± 17 SD (min = 11, max = 78 years old).In the control group the selection for this people is casual. These patients may or may not suffer from any other disease. 20% of them were male and 80% were females. The average age 38.54 years old ± 16.53SD (min = 1, max = 72 years old).

Results: In the psoriatic patients group the average value of vit D was 16.623 ± 6.35 SD, (min = 6.08 ng/ml, max = 37.4 ng/ml).4 patients or 8% had a Vit D level between 0–10 ng/ml, 29 patients or 58% had a Vit D level between 11–20 ng/ml, 15 patients or 30% had a Vit D level between 21–30 ng/ml. Only 2 patients or 4% had a normal Vit D level >30 ng/ml. There is no difference of the average value of vit. D between males and females in this group. In the control group the average value of vit D was 19.8 ± 6.86 SD(min = 5.61 ng/ml, max = 35 ng/ml). 4 patients or 8% had a Vit D level between 0–10ng/ml, 21 patients or 42% had a Vit D level between 11–20 ng/ml, 22 patients or 44% had a VitD level between 21–30 ng/ml. Only 2 patients or 6% had a normal Vit D level >30 ng/ml. There was a higher value of vit D in males without psoriasis, compared to women.

Conclusion: There was reduced vitamin D level in psoriatic patients when compared to healthy controls. The number of people with vit D deficiency and sufficiency was equal in both groups. The number of people with vit D insufficiency was higher in the psoriatic group.

Keywords: 25–OH Vitamine D, serume level, Psoriasis.