Endocrine Abstracts

Introduction: Cushing’s disease is diabetogenic due to the insulin resistance generated by the stimulating effect of glucocorticoids on neoglucogenesis and hepatic glycogenolysis.

Goal

Aim of our work is to study the frequency and characteristics of diabetes mellitus during Cushing’s disease.

Material and Methods: Retrospective study of a sample of 100 patients collected between (January 1983 – December 2009) in the endocrinology department of the CPMC.

Results: The frequency of diabetes mellitus in our series is 58.5%, (n = 58 p), the average age is 40 years, with a sex ratio of 3/1 (3F, 1H), diabetic inheritance is present in 75% of cases, the average BMI of our diabetic patients is 29.5 kg / m 2, the average CLU is 826 mg / 24 h, hypertension and dyslipidemia represent 80% and 52% respectively. Half of our patients (n = 29) are treated with insulin therapy (insulin alone n = 19, mixed treatment: insulin + oral treatment n = 10). The good glycemic balance under treatment was obtained in 30% (n = 17p), the average glycemic for all our diabetics is 2.33 g / l for fasting glycemia, extremes (1.4– 3.6), and 2.56 g / l for post prandial, extremes (1.7 – 4.2).

Conclusion: The high prevalence of diabetes mellitus during cushing’s disease requires rigorous monitoring with early detection of the other atherogenic risk factors which are often associated in order to improve management and to prevent complications, especially cardiovascular, which can initiate vital prognosis.