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Endocrine Abstracts (2020) 70 EP587 | DOI: 10.1530/endoabs.70.EP587

ECE2020 ePoster Presentations Hot topics (including COVID-19) (57 abstracts)

RHO gene polymorphisms in patients with Graves’ disease

Suzan Tabur 1 , Elif Oguz 2 & Tuncay Demiryurek 3


1Gaziantep University, Internal Medicine, Gaziantep, Turkey; 2Istanbul Medeniyet University, Medical Pharmacology, Istanbul, Turkey; 3Gaziantep University, Medical Pharmacology, Gaziantep, Turkey


Graves’ disease (GD) is an organ-specific autoimmune disorder of the thyroid due to the presence of circulating anti-thyroid-stimulating-hormone receptor stimulating autoantibodies that lead to hyperthyroidism. Involvement of the genetic variants of RHO genes in GD has not been examined yet. Therefore, the aim of this study was to investigate possible associations between RHO gene polymorphisms and GD in a Turkish population. A total of 128 patients with GD and 163 healthy control subjects were included to this study. Genomic DNA was extracted from whole peripheral blood samples and analyzed using the dynamic array system (Fluidigm, South San Francisco, CA, USA). The Chi-square or Fisher’s exact tests were used for calculation of the differences in frequencies. The Bonferroni correction for multiple testing was used for polymorphism studies, and P < 0.0071 (0.05/7) was considered statistically significant. We investigated 7 RHO gene polymorphisms. Neither genotype distributions nor the allele frequencies for the RHOA rs6784820, RHOA rs974495, RHOA rs2177268, RHOC rs11102522, RHOD rs2282502 (Asp88 Glu), RHOD rs34270544 (Arg144 Gln), and RND3 (RHOE) rs816890 polymorphisms showed a significant association between the groups. This study showed for the first time that there were no associations between studied RHO gene polymorphisms and the risk of developing GD in the Turkish population.

This study was supported by a project (SBAG-213S021) from the TUBITAK, Ankara, Turkey.

Table 1 The genotype and allele distrubition of RHO gene polymorphisms in Graves patients and control group.
Gen/SNPGenotype/AllelControln*Patientn*P
RHOA AA/AG/GG 65/63/30 158 56/38/28 122 0.3109
rs6784820 A/G 193/123 150/94 0.9930
RHOA CC/CT/TT 87/54/20 161 84/26/18 128 0.0435
rs974495 CT 228/94 194/62 0.2136
RHOA TT/TA/AA 89/33/41 163 80/17/29 126 0.2267
rs2177268 T/A 211/115 177/75 0.1901
RHOA AA/AG/GG 89/43/23 155 71/23/12 106 0.2968
rs11102522 A/G 211/89 165/47 0.1163
RHOD GG/GA/AA 66/58/37 161 54/39/29 122 0.7684
rs2282502 (Asp88 Glu) G/A 190/132 147/97 0.8328
RHOD CC/CT/TT 157/4/0 161 126/2/0 128 0.6966
rs34270544 (Arg144 Gln) C/T 318/4 254/2 0.6981
RND3 (RHOE) CC/CT/TT 153/9/0 162 119/8/0 127 0.8061
rs816890 C/T 315/9 246/8 0.8088

Volume 70

22nd European Congress of Endocrinology

Online
05 Sep 2020 - 09 Sep 2020

European Society of Endocrinology 

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