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Endocrine Abstracts (2021) 73 AEP397 | DOI: 10.1530/endoabs.73.AEP397

ECE2021 Audio Eposter Presentations Endocrine-Related Cancer (25 abstracts)

Anticancer activity of hydroxytyrosol and five semisynthetic lipophilic derivatives in prostate cancer cells

Antonio J. León-González1, 2, 3, 4, Prudencio Sáez-Martínez1, 2, 3, 4, Juan M. Jiménez-Vacas5, Vicente Herrero-Aguayo1, 2, 3, 4, Antonio J. Montero-Hidalgo1, 2, 3, 4, Enrique Gómez-Gómez1, 3, Andrés Madrona6, Justo P. Castaño1, 2, 3, 4, José L. Espartero6, Manuel D. Gahete1, 2, 3, 4 & Raúl M. Luque1, 2, 3, 4


1Maimonides Institute of Biomedical Research of Cordoba (IMIBIC), Córdoba, Spain; 2University of Cordoba, Department of Cell Biology, Physiology and Immunology, Córdoba, Spain; 3Reina Sofia University Hospital (HURS), Córdoba, Spain; 4CIBER Physiopathology of Obesity and Nutrition (CIBERobn), Córdoba, Spain; 5Institute of Cancer Research, Translational Therapeutics and Cancer Biomarkers Team Division of Clinical Studies, Sutton, London, United Kingdom; 6University of Seville, Department of Organic and Pharmaceutical Chemistry, Seville, Spain


Prostate cancer (PCa) is the second most diagnosed cancer type and the sixth cause of cancer death among men worldwide. Due to the usual slow course of the progression of this disease, there is a growing interest in finding chemopreventive therapeutics with a low risk of side effects. In line with this, recent studies have shown that hydroxytyrosol (HT), one of the main extra virgin olive oil phenolic compounds, exerts a protective role against different cancer types. Moreover, semisynthetic derivatives of HT could improve its bioavailability and pharmacological activities. Thus, in this study we aimed to compare the in vitro anticancer effects of HT and five semisynthetic derivatives, including alkyl ethers, esters, and nitro-derivatives against different PCa cell lines. Antiproliferative effects of HT and two lipophilic derivatives [hydroxytyrosyl acetate (HT-Ac) and ethyl hydroxytyrosyl ether (HT-Et)] were significantly higher in cancerous PC-3 and 22Rv1 cells than in non-malignant RWPE-1 cells, whereas the nitro-derivatives were more cytotoxic in RWPE-1. In addition, HT, HT-Ac and HT-Et significantly reduced migration capacity in RWPE-1 and PC-3 as well as prostatosphere size and colony formation in 22Rv1 cells. Nevertheless, HT-Ac and HT-Et, but not HT, were able to decrease phospho-AKT/AKT levels and colony and prostatosphere formation in PC-3. In sum, our results together with previous studies showing the antioxidant capacity of HT and its lipophilic derivatives suggest that they could be considered as potential therapeutic tools in PCa.

Funding

Junta de Andalucía (PI-0152-2019/RH-0084-2020/BIO-0139), MINECO (PID2019-105564RB-I00/FPU17-00263, FPU16-06190/FPU18-02485), ISCIII (PI16-00264), University of Cordoba (Programa Operativo FEDER Andalucía: 27 416), and CIBERobn.

Volume 73

European Congress of Endocrinology 2021

Online
22 May 2021 - 26 May 2021

European Society of Endocrinology 

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