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Endocrine Abstracts (2021) 73 AEP643 | DOI: 10.1530/endoabs.73.AEP643

ECE2021 Audio Eposter Presentations Thyroid (157 abstracts)

Assessment of hearing impairment in adult patients with euthyroid Hashimoto’s thyroiditis

Ömercan Topaloğlu 1 & Bayram Şahin 2


1Kocaeli Derince Training and Research Hospital, Endocrinology, Derince/Kocaeli, Turkey; 2Kocaeli Derince Training and Research Hospital, Otorhinolaryngology, Derince/Kocaeli, Turkey


Introduction

Hearing loss may be associated with autoimmune diseases, but it was less studied in Hashimoto’s thyroiditis (HT). We aimed to evaluate hearing impairment by audiometric assessments in adults with euthyroid HT.

Materials and Methods

Adult patients with euthyroid HT (normal thyroid functions, positive AntiTPO/AntiTg and sonographic findings) were compared with controls. We excluded pregnant or older patients (>50-year-old), those with history of otological/audiological disease or surgery, otitis media, acoustic trauma, chronic illnesses, use of alcohol, cigarette, medications, rheumatoid factor, antinuclear, antimitochondrial, antiparietal, antineutrophil cytoplasmic, anti-smooth muscle, or antigliadin antibodies, abnormal biochemical or otological findings. Tympanometry which indicated tympanic peak pressure (TPP, daPa), acoustic reflex testing (ART), pure tone average (PTA), and transient evoked otoacoustic emission (TEOAE) were performed. We grouped the participants according to ART (positive/negative), TEOAE (normal/undetected), PTA (≤20/>20 dB).

Results

Air conduction thresholds on right ear at 500, 4000, 6000, 8000 Hz, PTA average, and left ear at 250, 4000, 6000, 8000 Hz were higher in euthyroid HT (n = 36) than in controls (n = 40) (P<0.05). We found less negative TPP and a higher ratio of negative ART in euthyroid HT (P<0.05). Euthyroid HT predicted undetected TEOAE and increased hearing threshold on right ear at 500 and 8000 Hz (P<0.001). TEOAE detected hearing impairment at a higher rate. AntiTPO level was positively correlated with TPP and air conduction thresholds except right ear at 8000 Hz.

Table 1. Logistic regression analysis showing the association between categorical parameters and HT.
Parameters Univariate Multivariate
OR(95% CI) P value OR(95% CI) P value
fT4(normal-high/
normal-low)
8.000(2.832–22.72) <0.001 11.20(3.10–40.35) <0.001
ART L ipsilateral(positive/negative) 2.250(1.738–2.913) 0.046    
ART L contralateral(positive/negative) 2.250(1.738–2.913) 0.046    
TEOAE(normal/
undetected)
2.666(1.941–3.663) <0.001 NA <0.001
Hearing threshold (≥20/>20 dB)        
R PTA average 2.252(1.739–2.915) 0.030    
R air 500 Hz 2.252(1.739–2.915) 0.030 NA <0.001
R air 4000 Hz 2.288(1.757–2.985) 0.015    
R air 6000 Hz 2.427(1.828–3.225) 0.002    
R air 8000 Hz 2.597(1.912–3.533) <0.001 NA <0.001
L air 250 Hz 2.252(1.739–2.915) 0.030    
L air 4000 Hz 2.252(1.739–2.915) 0.030    
L air 6000 Hz 2.380(1.805–3.134) 0.003    
L air 8000 Hz 2.427(1.828–3.225) 0.002    
R:right L:left

Conclusions

Hearing may be impaired in euthyroid HT. We recommend close monitoring of hearing functions in these patients. TEOAE more specifically indicates hearing impairment.

Volume 73

European Congress of Endocrinology 2021

Online
22 May 2021 - 26 May 2021

European Society of Endocrinology 

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