ECE2021 Audio Eposter Presentations Calcium and Bone (75 abstracts)
The bone impact of body composition, adipokines and FGF23-Klotho axis in active acromegaly
Stefana Bilha 1 , Anca Matei 1 , Daniela Constantinescu 2 , Mariana Pavel-Tanasa 2 , Raluca Mogos-Cioncu 1 , Petru Cianga 2 , Cristina Preda 1 & Dumitru D. Branisteanu 1
1’St. Spiridon’ Hospital, ’Grigore T. Popa’ University of Medicine and Pharmacy, Endocrinology Department, Iasi, Romania; 2’St. Spiridon’ Hospital, ’Grigore T. Popa’ University of Medicine and Pharmacy, Immunology Department, Iasi, Romania
Introduction
Body composition (BC), adipokines and the fibroblast growth factor-23 (FGF23) - Klotho axis interfere with bone metabolism and also suffer important modifications in acromegaly. We aimed to investigate their influence upon bone in active acromegaly, compared to controls.
Methods
We performed a cross sectional study, investigating the adipokines (leptin, adiponectin, resistin) secretion pattern, BC parameters and FGF23-α-Klotho axis and their impact upon bone mineral density (BMD) and turnover, respectively, in 35 patients with active acromegaly (Acro), compared to sex, age and body mass index (BMI) - matched healthy controls (Ctl).
Results
Acro had higher lumbar and femoral neck Z-scores (P < 0.05), respectively, and a lower trunk-to-leg fat ratio compared to Ctl. Serum adipokines, but not FGF23, differed significantly in the two groups, with lower leptin (P < 0.001) and elevated adiponectin (P < 0.001) and resistin (P = 0.001) concentrations in the Acro group. Resistin was also higher in non-diabetic Acro compared to Ctl (15.9 ± 4.26 ng/ml vs 6.59 ± 0.66 ng/ml, P = 0.048). Age (negative), lean mass and trunk-to-leg fat ratio (positive) were the main independent BMD predictors in regression analysis in both Acro and Ctl. Adiponectin and resistin negatively correlated with BMD at various sites (P < 0.05) and α-Klotho was positively correlated with osteocalcin (r = 0.52, P = 0.003) in the Acro, but they lost significance after adjusting for age and BC.
Conclusions
Acromegalic patients display important BC, adipokines and bone changes. Age and BC were the main independent BMD predictors in active acromegaly, similar to the general population. Although serum adipokines showed an altered profile, related to the metabolic changes seen in acromegaly, they were not found to have independent bone actions.
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Endocrine Abstracts
ISSN 1470-3947 (print) | ISSN 1479-6848 (online)
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