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Endocrine Abstracts (2022) 81 EP219 | DOI: 10.1530/endoabs.81.EP219

ECE2022 Eposter Presentations Calcium and Bone (114 abstracts)

Is obesity detrimental to postmenopausal bone health?

Radina Dimitrova 1 , Mila Boyadzhieva 1 , Kiril Hristozov 1 & Yana Bocheva 2


1MU Varna, Second Department of Internal Medicine, Varna, Bulgaria; 2MU Varna, Department of Clinical Laboratory, Varna, Bulgaria


Introduction: Despite available evidence for a relationship between bone health and obesity, the results of clinical trials remain conflicting. Thus, we conducted a cross-sectional study to analyze possible associations between waist circumference (WC), body mass index (BMI) and body weight (BW) with bone health in postmenopausal women.

Materials and Methods: The study included 84 women from Northeastern Bulgaria. Their mean age was 60.54±7.07 years, and their mean duration of menopause was 11.45±6.62 years. Bone health was assessed by dual-energy X-ray absorptiometry (DEXA), analysis of bone metabolic markers and fracture risk calculation.

Results: According to BMI 31% of the subjects were with normal weight, 50% were overweight and 20% were obese. In 82% of the women WC was over 80 cm. Significant positive correlations of bone mineral density (BMD) with WC (L1-L4 r=0.264; P=0.015, Femoral Neck r=0.338; P=0.002, Total Neck r=0.393; P < 0.001), BMI (L1-L4 r=0.295; P=0.006, Femoral Neck r=0.223; P=0.042, Total Neck r=0.330; P=0.002) and BW (L1-L4 r=0.446; P 0.001, Femoral Neck r=0.409; P 0.001, Total Neck r=0.457; P 0.001) were found. However, after BW adjustment the correlations of BMD with WC and BMI became insignificant. Moreover, a negative association was found between Femoral Neck BMD and BMI after BW adjustment (r=-0.260; P=0.018). On the other hand, the positive relationship between BMD and BW remained significant after WC and BMI adjustment. In addition, WC was inversely related to osteocalcin (r=-0.217; P=0.048) and Beta CrossLaps (r=-0.226; P=0.039). Nevertheless, a positive relationship was found between WC and pyrilinks D/creatinuria ratio (r=0.277; P=0.011), but it was associated with higher eGFR in obesity. Furthermore, higher BW was noted as a significant negative predictor of the 10-year risk of major osteoporotic fracture (MOF) (β=-0.730, P0.001) and hip fracture (HF) (β=-0.730, P0.001), but positive associations were found between BMI and the both fracture risks (for MOF β=0.532, P=0.009; for HF (β=0.441, P=0.026).

Conclusion: We assumed that obesity might be detrimental to postmenopausal bone health, as it was associated with lower BMD, lower bone turnover and higher fracture risks.

Volume 81

European Congress of Endocrinology 2022

Milan, Italy
21 May 2022 - 24 May 2022

European Society of Endocrinology 

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