Endocrine Abstracts

Introduction: Homeostasis of calcium and phosphor influence bone metabolism. They depend on several hormones, including parathyroid hormone, thyroid and sexual hormones. Low bone mass seems a common issue in endocrine disorders. The aim of this study is to identify the different endocrine disorders in patients with low bone mass.

Methods: Retrospective study collecting the medical files of patients followed in the endocrinology department of Charles Nicolle Hospital between the years 2018 and 2021. The exclusion criteria are: patients followed for a systemic disease or rheumatic disease and patients who received corticosteroid therapy.

Results: We have studied 50 consecutive patients (14 males, 36 females, sex ratio 0.38, aged 8-88 years). Postmenopausal women represented 56% of the study population.We measured bone mineral density (BMD) at the hip: 70% of patients had osteoporosis (36% males, 64% females) and 30% had osteopenia (12% males, 88% females). The average of T score was -2,78 (min -6; max 0.8) for the spine and -2,09 (min -4,7;max 0,7) for the femur neck with a significant correlation between them. 44% of patients were at a risk of fracture and 2% had a pathological fracture. According to the type of endocrinopathy: 62% of patients had hyperparathyroidism (63,3% osteoporosis; 36.7% osteopenia), 12% had hypogonadotropic hypogonadism (85,7% osteoporosis; 14,3% osteopenia), 10% had hyperthyroidism, 8% had primary ovarian insufficiency (25% osteoporosis; 75% osteopenia) and 2% had hyperadrenocorticism (50% osteoporosis; 50% osteopenia).

Conclusion: Additional studies are needed to further understand the endocrine secondary osteoporosis in order to establish evidence based guidelines about its diagnosis, evaluation, treatment and follow up.