Searchable abstracts of presentations at key conferences in endocrinology
Endocrine Abstracts (2022) 86 OP1.4 | DOI: 10.1530/endoabs.86.OP1.4

1Clinical Research Centre, Medical University of Bialystok, Bialystok, Poland; 2Department of Endocrinology Diabetology and Internal Medicine, Medical University of Bialystok, Bialystok, Poland


Differentiated thyroid cancer (DTC) is the most common malignant neoplasm arising from the thyroid parenchymal cells. DTC risk stratification is a multi-stage process based on investigated histopathological features and ultrasound test outcomes combined with biochemical test results. Thus, searching for novel diagnostic indicators useful in cancer risk stratification are still needed. Recent studies revealed that oxidative and epigenetic alterations in DTC represent the signature of the disease that could be useful in early detection and diagnosis. Moreover, it was proved that nuclear factor kappa B (NF-kB), forkhead box protein 01 (FOXO), interleukin 6 (IL-6) and oxidative stress play a crucial role in DTC progression. Therefore, the determination of their role may be useful in DTC personalized clinical management. In this case, we analyzed the level of oxidative stress-related proteins, such as total oxidative stress capacity (TOC), total antioxidant capacity (TAC), NF-kB, FOXO and IL-6 to determine their role in DTC risk stratification particularly in intermediate-risk DTC progression detection. For this study 80 patients diagnosed with different stages of DTC after total thyroidectomy were enrolled. All patients were diagnosed as having papillary DTC based on laboratory tests and ultrasound imaging, and confirmed by FNAB, followed by histopathological examination. The study group consisted of DTC patients with intermediate risk based on American Thyroid Association (ATA) stratification. For the reference group low risk DTC patients were enrolled. The TAC, NF-kB, FOXO and IL-6 demonstrated increased levels among DTC intermediate risk group comparing to low risk DTC reference group (all P<0.05). Moreover, these measurements could be implicated as additional tools in intermediate DTC risk stratification (AUC= 0.68; AUC=0.67; AUC=0.7; AUC=0.69; all P<0.05 respectively). Our study suggested the utility of all studied parameters during DTC risk stratification, where FOXO and IL-6 assessments were characterized by the highest diagnostic utility.

Volume 86

Society for Endocrinology BES 2022

Harrogate, United Kingdom
14 Nov 2022 - 16 Nov 2022

Society for Endocrinology 

Browse other volumes

Article tools

My recent searches

No recent searches.