Endocrine Abstracts

We performed this study to identify factors related to intact incretin levels in patients with type 2 diabetes (T2D). We cross-sectionally analyzed 336 patients with T2D. Intact glucagon-like peptide 1 (iGLP-1) and intact glucose-dependent insulinotropic polypeptide (iGIP) levels were measured in a fasted state and 30 min after ingestion of a standard mixed meal. The differences between 30 and 0 min iGLP-1 and iGIP levels were indicated as ΔiGLP-1 and ΔiGIP. After in...

Introduction: Endocrine complications are common in patients with thalassaemia major. Currently, there is no literature studying the prevalence of endocrine abnormalities within a British cohort of children with transfusion-dependent thalassaemia. Existing literature is mostly based on Greek and other Mediterranean thalassaemia populations, and variations in local management guidelines may result in different clinical outcomes. This study aimed to audit recomm...

Objective: Among women over 40 the prevalence of goiter in Poland is over 40% and the prevalence of vitamin D deficiency is over 80%. There have not been any previous studies that investigate the vitamin D level in women with and without goiter.Methods: 152 women-96 with and 56 without nontoxic goiter were examined in 2014. In US examination we calculated the volume of the thyroid gland and volume of nodules. Blood samples for 25-(OH) D total were taken....

52 years old man medicated with amiodaron 12 months, with laboratory confirmed hyperthyroidism, in us-examination 45 ml Basedow goiter, TRAb positive; ventricular tachycardia 180/min intermittent with sinusal tachycardia 120/min, thiamasol 120 mg i.v./daily, hydrocortisone 400 i.v. daily, crystalloids, beta blockers, diazepam, albumin. J131 scintigraphy – no iodine uptake. natriumperchlorate 1500 mg daily initially, continued next month 900 mg coused iodine uptake 17%. Fi...

Fludioxonil, a phenylpyrrole fungicide, is extensively used to protect particularly fruits and vegetables from fungi. On the contrary, it has been reported that fludioxonil caused low weight birth in rats at parentally toxic doses. However, its developmental toxicity on cardiac differentiation has not yet been understood. In the present study, the early developmental toxicity of fludioxonil on the cardiac differentiation of mouse embryonic stem cells (mESCs) was evaluated. Fir...

Introduction: Studies suggest that disturbed thyroid hormones (TH) homeostasis may lead to increased cancer risk. However, the exact role of TH in cancerogenesis is unknown. We have previously identified 15 genes linked with TH signaling in 7 cancer types and 10.967 cancer patients. Here, we investigated the influence of hypothyroidism on the expression of these 15 genes in rat tissues/organs from which the previously identified, TH-related cancer types originate.<p class=...

Backgrounds: Mutiplicity of papillary thyroid carcinoma (PTC) are not an unusual finding, although the origin of these foci is unclear. Either intraglandular metastases from a single dominant tumor or unrelated neoplastic clones were definitively proven as the means by which multicentric PTC form. In addition, there is insufficient clinical information concerning multicentric PTC presentation, prognosis, and long-term follow-up studies after treatment. Multiplicity of PTC has ...

A 69-year-old non-diabetic woman presented with 1 month of recurrent drowsiness and confusion secondary to hypoglycaemia, nocturnal and on fasting. On admission her CBG was 2.6 mmol/l, confirmed venously. Her history was of a large solitary fibrous tumour (SFT) of the chest wall first resected in 2011 with recurrent relapses requiring surgery in 2016 and 2017. Histology showed typical features of SFT. Despite palliative chemo-radiotherapy for a further relapses, there was prog...

Background: The Covid-19 pandemic has led to various unprecedented challenges and obstacles, especially in the field of Diabetes and Metabolism, many of which are as novel as the pandemic itself. Discovering efficacious therapeutic options resulting in positive outcomes has been a challenge. Dexamethasone has been shown to reduce mortality in patients with Covid-19 pneumonitis who require oxygen therapy and/or ventilation. Exogenous steroid therapy is renowned to cause adverse...

Background: Lead is known as an environmental toxic pollutant and hormonal regulatory confounder associated with obesity. Recent China scientific report shows that blood lead level (BLL) is closely related with body mass index. Therefore, we investigated the association between the prevalence of metabolic syndrome and blood lead levels in healthy general population without hypertension, dyslipidemia, and diabetes.Methods: We assessed the socio-demographi...