Endocrine Abstracts

Introduction: Polycystic ovary syndrome (PCOS) is a common endocrine system disorder among women of reproductive age. Although some studies have suggested an association between PCOS and autoimmune thyroiditis, only a few cases indicating association between PCOS and Graves’ disease are reported.Case report: We present a woman aged 29 with Graves' disease certified by suppressed TSH (0.001 mUI/l), high FT4 (6.6 ng/dl) associated with elevated TRAb (...

Background: Primary autoimmune hypophysitis (PAH) is a rare chronic inflammatory condition of the pituitary gland that occurs more commonly in females during pregnancy or in the post-partum period. It is strongly associated with other autoimmune disorders. The various forms of hypophysitis are misdiagnosed as pituitary adenoma in 40% cases.Objective: First of all, we propose to present a case of PAH associated with other autoimmune diseases. Our second a...

Normocalcemic primary hyperparathyroidism (NPH) is characterized by normal total and ionized serum calcium concentrations and consistently elevated PTH levels. These patients have no obvious causes for secondary elevations of PTH, such as renal disease, vitamin D deficiency or malnutrition. The group consisted of 22 postmenopausal women, six premenopausal women, and two men, aged 58±2 years (range 31–77) investigated between 2011 and 2016.Resul...

Introduction: Paget’s disease of bone (PDB) is the second-most-common metabolic bone disease, after osteoporosis, affecting about 3% of the population at age over 40 years. This disease is characterized by excessive and abnormal bone remodeling due to increased bone resorption followed by disorganized bone formation.This paper will include a case report and a review of PDB epidemiology and pathophysiology, complications and clinical findings, indica...

Introduction: Neuroendocrine tumours (NET) represent ~20% of all primary neoplasms of the lung. Histologic confirmation is important for treatment and prognosis determination. NET are classified according to four subtypes in the lung: typical carcinoid tumour (TC), atypical carcinoid tumour (AC), small cell carcinoma (SCC), and large cell neuroendocrine carcinoma (LCNEC). TC is low-grade, AC is intermediate-grade, and SCC and LCNEC are high-grade malignancies.<p class="abs...

Introduction: Neuroendocrine tumors (NET) represent ~20% of all primary neoplasms of the lung. Histologic confirmation is important for treatment and prognosis determination. NET are classified according to four subtypes in the lung: typical carcinoid tumor (TC), atypical carcinoid tumor (AC), small cell carcinoma (SCC), and large cell neuroendocrine carcinoma (LCNEC). TC is low-grade, AC is intermediate-grade, and SCC and LCNEC are high-grade malignancies.<p class="abstex...

Clear cell renal carcinoma (CCRC) is a tumor with great metastatic capacity, although the presence of metastases in the thyroid gland is very uncommon. Therefore it is important to know the oncological background of the patient and to perform a complete immunohistochemical analysis of the thyroid lesion to obtain a correct diagnosis. Thyroidectomy can be considered in patients with no other metastasis or in those who present compressive symptoms as a palliative measure. We pre...

Autoimmune polyglandular syndromes (APS) are characterized by the association of two or more endocrine and/or nonendocrine autoimmune diseases with different immunologic features of their pathogenesis.Based on the clinical picture is divided into four different types. Type I APS comprises mucocutaneous candidiasis, hypoparathyroidism and Addison’s disease. Type II APS is defined by autoimmune Addison’s disease in association with chronic autoim...

Chronic autoimmune thyroiditis and Graves’ disease (GD) are two forms of autoimmune thyroid disease (AITD).The association of GD or other thyrotoxic forms of autoimmune thyroiditis with one or several toxic nodules is the Marine – Lenhart syndrome (SML). It is a rare pathology with prevalence between 2.7 and 4.1%. Its physiopathology remains complicated and misunderstood, incriminating antithyroidian auto-antibodies such as TSH re...

Introduction: Tertiary hyperparathyroidism (HPT) occurs most commonly in the setting of renal transplant where patients with secondary HPT continue to have elevated PTH levels after receiving a renal allograft. This disease is observed in up to 30% of kidney transplant recipients. This paper will include a case report and a review of epidemiology and pathophysiology, complications and clinical findings, indications for treatment, and the drugs currently available to treat this...