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Endocrine Abstracts (2023) 90 P316 | DOI: 10.1530/endoabs.90.P316

1Endocrinology and Nutrition Unit, San Cecilio Clinical University Hospital, Granada, Spain; 2Institute of Biosanitary Research of Granada (ibs.GRANADA), Granada, Spain; 3Nuclear Medicine Unit, San Cecilio Clinical University Hospital, Granada, Spain; 4Clinical Analysis Unit, San Cecilio Clinical University Hospital, Granada, Spain; 5CIBER on Frailty and Healthy Aging (CIBERFES), Carlos III Health Institute, Granada, Spain; 6Department of Computer Science and Artificial Intelligence, University of Granada, Granada, Spain; 7Andalusian Institute for Research in Data Science and Computational Intelligence, (Instituto DaSCI), Granada, Spain; 8Department of Medicine, University of Granada, Granada, Spain

Introduction: Hypophosphatasia (HPP) is an inherited disease, characterized by a non-tissue-specific alkaline phosphatase deficiency that leads to abnormal mineralization of bone tissue, which promotes fragility fractures. A defective muscle status could have important clinical repercussions on fracture risk. The aim of this work was to evaluate the relationship between bone and muscle compartment.

Material and Methods: Observational cross-sectional study in adults with PPH. Demographic (age, sex), analytical (alkaline phosphatase (ALP), normal range: 30-120 U/l), and clinical variables (fractures, kilograms (kg) of muscle strength with Jamar dynamometer -cut-off point: <p10 of Spanish population-, rectus femoris quadriceps muscle mass with ultrasound -Sonosite S-Nerve®- and bone mineral density with dual energy X-ray absorptiometry expressed according to T and Z-score. Statistical analysis was performed with IBM SPSS v.25.

Results: Twenty-one subjects were studied. 54% women, mean age: 49±18 years. The mean FA was 28±12U/l. 41% presented at least 1 bone fracture. Mean dynamometry was 28±11kg, 100% with good muscle strength. In the nutritional morphological assessment, the mean Y-axis measurement was 1.5±0.7 and muscle area, 4.8±2.5. The mean T-score in lumbar spine (L1-L4) was -0.8±1.5 and in femoral neck (FC) -1.3±0.9. The mean Z-score in L1-L4 was 0.08±1 and in CF 0.06±1.1. Muscle strength was positively correlated with Y-axis (r=0.52, P=0.02), with muscle area (r=0.51, P=0.02), with T and Z-score in CF (r=0.64, P=0.002) and with T and Z-score in L1-L4 (r=0.51, P=0.02).

Conclusions: There is a high prevalence of fractures in patients with PPH. A positive correlation was observed between the muscle and bone compartments. Therefore, enhancing the muscle compartment in PPH patients could reduce the risk of fracture in these patients.

Volume 90

25th European Congress of Endocrinology

Istanbul, Turkey
13 May 2023 - 16 May 2023

European Society of Endocrinology 

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