Endocrine Abstracts

Introduction: Celiac disease and growth hormone deficiency can sometimes coexist, presenting a unique clinical challenge. Celiac disease, an autoimmune condition triggered by gluten consumption in genetically predisposed individuals, can lead to malabsorption and various complications. Growth hormone deficiency (GHD) refers to inadequate production of growth hormone, affecting normal growth and development.

Objective: To explore the association between celiac disease and growth hormone deficiency.

Patients and Methods: This is a retrospective descriptive study based on the records of patients followed in our department for growth retardation (GR), where the diagnoses of growth hormone (GH) deficiency and celiac disease (CD) were established.

Results: Our study focused on 4 patients with an average age of 15.5 years, predominantly male (3 boys and 1 girl). All patients were monitored for celiac disease, with initial positive anti-transglutaminase antibody titers. In the absence of growth despite 3 years of a gluten-free diet, GH deficiency was suspected and confirmed by low IGF-1 levels in all cases. Pituitary MRI was normal in all cases. Management involved initiating substitutive growth hormone therapy, resulting in an average height gain of 1.1 SD±2 SD in the first year.

Conclusion: The coexistence of celiac disease and growth hormone deficiency requires a comprehensive and multidisciplinary approach. Timely diagnosis and appropriate management, including a gluten-free diet and growth hormone replacement therapy, can significantly impact the overall well-being and growth trajectory of affected individuals. Regular monitoring and collaboration between gastroenterologists and endocrinologists are essential for optimal outcomes in such case.