The association of neutrophil/HDL ratio, plasma atherogenic index and several cardiovascular risk scoring systems in acromegaly

Kocabaş Gokcen Unal; Damla Kuşat; Elif Azarsiz; Yurekli Banu Sarer

doi:10.1530/endoabs.110.EP1182

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Endocrine Abstracts (2025) 110 EP1182 | DOI: 10.1530/endoabs.110.EP1182

ECEESPE2025 ePoster Presentations Pituitary, Neuroendocrinology and Puberty (220 abstracts)

The association of neutrophil/HDL ratio, plasma atherogenic index and several cardiovascular risk scoring systems in acromegaly

Gökçen Ünal Kocabaş ¹ , Damla Kuşat ¹ , Elif Azarsiz ² & Banu Sarer Yurekli ¹

Author affiliations

¹Ege University, Endocrinology, Izmir, Türkiye; ²Ege University, Clinical Biochemistry, Izmir, Türkiye.

JOINT3595

Acromegaly is associated with an increase in cardiovascular risk factors and cardiovascular disease mortality, and endothelial dysfunction. Acromegaly is also associated with subclinicasl inflammation. There is growing interest in indices derived from complete blood count due to the small cost and easy accessibility. Research has shown that Neutrophile-leucocyte ratio and platelet- leucocoyte ratio are higher in acromegalic patients compared to non-functioning pituitary adenomas. The neutrophil to HDL-cholesterol ratio (NHR) is a composite marker reflecting inflammation and lipid metabolism. NHR is a strong predictor of cardiovascular disease in many studies. To date, there are no studies of NHR in acromegaly. In this study, we aimed to determine hematological markers and the relationship between cardiovascular risk scores in acromegalic patients and healthy controls.

Methods: We retrospectively evaluated the hematological markers and lipid profiles of acromegaly patients and healthy controls. We calculated SCORE-2 and Framingham risk scoring systems and SCORE-DM system for diabetics. The patients with established cardiovascular disease were excluded.

Results: 126 of the 204 patients were acromegaly and 78 were age and gender matched controls. There was no significant difference in Framingham and SCORE risk scores, neutrophile-leucocyte ratio(NLR), platelet-lymphocyte ratio (PLR) atherogenic index of plasma (AIP), neutrophile-HDL ratio(NHR) and platelet HDL ratio(PHR)between acromegaly and control groups. According to the remission status, the studied parameters did not show statistically significant difference. In the acromegaly group GH levels were positively correlated with SCORE risk (r²:0.303, P = 0.01)IGF-1 levels showed a weak positive correlation with NHR(r²:0.202, P = 0.028).

Discussion: We failed to demonstrate any significant difference in CBC derived indices of inflammation in acromegaly patients. Further studies indicating the effects of treatment modalities along with other indices of atherosclerosis are needed to determine the role of CBC derived parameters in acromegaly and atherosclerosis.