Challenge in the follow-up of a type 1 diabetic patient with short stature - how craniopharyngioma can disturb the hormone status

Zsuzsanna Berdo; Andrea Nagy; Laszlo Novak; Enikő Felszeghy

doi:10.1530/endoabs.110.EP523

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Endocrine Abstracts (2025) 110 EP523 | DOI: 10.1530/endoabs.110.EP523

ECEESPE2025 ePoster Presentations Diabetes and Insulin (245 abstracts)

Challenge in the follow-up of a type 1 diabetic patient with short stature - how craniopharyngioma can disturb the hormone status

Zsuzsanna Berdó ¹ , Andrea Nagy ² , László Novák ³ & Enikő Felszeghy ²

Author affiliations

¹University of Debrecen, Pediatrics Clinic, Debrecen, Hungary; ¹University of Debrecen, Pediatrics Clinic, Debrecen, Hungary; ³University of Debrecen, Neurosurgery Clinic, Debrecen, Hungary

JOINT1298

A 14 year old boy with delayed puberty and short stature has been diagnosed with Type 1 (insulin-dependent) diabetes mellitus (T1DM). During the first six month of his diabetes treatment, in his honeymoon period, he did not required insulin substitution, but his short stature did not change, there was no growth velocity. Because of these symptoms, insulin tolerance- and glucagon stimulation test was performed after androgen priming. Growth hormone (GH) peak was not detectable in any stimulation test, the hormone concentrations were below the measurable limit. Brain MRI scan revealed a cystic intrasellar craniopharyngioma with moderate suprasellar extension. Chronic diseases like T1DM can cause short stature, but other organic failures could be also considered. Strict patient follow up can help to make the correct, complex diagnosis. After neurosurgical intervention hypoglycemic episodes can be life-threatening especially together with insulin replacement in T1DM, since counter regulatory hormones are missing.