Endocrine Abstracts

Introduction: Anaplastic thyroid cancers are undifferentiated malignancies accounting for 2% of thyroid cancers.Objective: To study the clinical, evolutionary and therapeutic characteristics of these carcinomas.Materials and methods: A retrospective study covering 7 cases collected at our ENT department between 1994 and 2021.Results: They were 6 women and one man with an average age of 50 (41-78). The reason ...

Introduction: Multiple endocrine neoplasia (MEN) is a rare genetic syndrome characterized by occurrence of tumors involving two or more endocrine glands. Four types are described: MEN1, MEN2, MEN3 and the recently identi&#-1279;ed MEN4. Due to the complexity of the syndromes, it is difficult to manage these patients. Our objective was to describe the clinical features of individuals from 7 families with a diagnosis of MEN1 or MEN2 and identify current challenges in clinical pr...

A 24-year-old traffic warden was initially referred to the neurology department with episodes of “funny turns” over the past 7 years. Without warning she would become dizzy and lightheaded with blurring of vision and weak legs. These symptoms would resolve after ingesting something sweet but the relief of her symptoms was not immediate. The episodes could happen at any time of the day but never first thing in the morning and could happen several times a week. She rep...

Introduction: Craniopharyngioma is a rare benign epithelial tumour arising from the pituitary stalk or pituitary gland, developing in the sellar and suprasellar region, it affects both adults and children, The clinical presentation may include endocrine symptoms suggestive of hypopituitarism, ophthalmologic symptoms, signs of intracranial hypertension and focal neurological signs. However, after surgical treatment, hypothalamic-pituitary endocrine damage is common. The aim of ...

Bone loss in chronic autoimmune inflammatory diseases is a major clinical problem. Inflammation-mediated osteoposis (IMO) is the first animal model of generalized osteoporosis resulting from inflammation. The P2×7 receptor, an ATP-gated ion-channel, is primarily expressed on immune and bone cells. ATP is now seen as a novel inflammatory mediator, with P2×7 as main target of the pro-inflammatory activity. The P2×7-receptor has a regulatory role in bone formation ...

Vascular calcification, occurring in organs such as heart and kidneys, is associated with increased risk of cardiovascular mortality. The underlying molecular mechanisms remain unknown. To elucidate these, we investigated C3H mice, an inbred strain susceptible to vascular, myocardial and renal calcification. Myocardial calcification in C3H mice involves 4 genetic loci, Dyscalc1-4, that map to chromosomes 7, 4, 12 and 14, respectively. Dyscalc1 contributes to myoc...

Introduction: The association of central diabetes insipidus (CDI) and acute myeloid leukaemia is rare. The onset of CDI is variable during the disease course and can be a presenting feature of AMLCase: : A 75 years old Caucasian male patient presented with acute right sided abdominal pain. His initial CT abdomen was normal. He had normocytic anaemia, thrombocytosis and monocytosis. A repeat CT scan 3 days later showed bilateral swollen adrenal glands and...

Introduction: Graves’ disease (GD) is an autoimmune disorder characterized by diffuse hyperplasia and excessive production of thyroid hormone. The association between thyroid carcinoma and GD is controversial. Thyroid nodular lesions in patients with GD should raise a high suspicion of carcinoma. The aim of this study is to focus on the possibility of an association between hyperthyroidism and thyroid Carcinoma.Materials and Methods: This is a retro...

Adrenal cortical carcinoma (ACC) is a rare malignancy, especially in children, and the annual worldwide incidence has been calculated as 0.3 cases per million children younger than 15 years old. We present a case of functioning ACC in a 7 years-old female child who manifested with virilization. She presented with low-pitched voice, excessive pubic hair growth, growth acceleration, clitoral enlargement and increased muscle strength at the age of six. Her blood pressure was norm...

Introduction: Oncogenic Osteomalacia (OO) is a rare paraneoplastic syndrome, resulting from fibroblast growth factor 23 overproduction. The rarity of the disease and nonspecific symptoms often cause delay in diagnosis by months, or even years. There are two cornerstones in the diagnostic process. The first concerns clinical identification, where awareness of this uncommon ailment combined with hypophosphatemia and clinical signs may be sufficient to identify OO. The second inv...