Endocrine Abstracts

Introduction: Graves’ thyrotoxicosis and Addison’s disease are disorders with a strong auto-immune basis. Primary hypothyroidism and Addison’s disease are recognised components of polyglandular autoimmune syndrome type II (PGA-II). Despite its autoimmune etiology, Graves disease is not commonly associated with PGA-II. We present a case of a patient with newly diagnosed Graves’ disease presenting in incipient adrenal crisis due to unrecognized Addison’s...

Introduction: We submit a rare presentation of primary hyperparathyroidism in pregnancy posing complex management difficulties.Case report: A 32-year-old Asian woman presented during third trimester of her pregnancy with symptoms of lethargy, leg pain, and weakness. Routine investigations revealed an elevated calcium level (3.83 mM) and PTH level of 231.1 ng/l. She was treated with i.v. fluids and pamidronate. An ultrasound of her thyroid gland showed a ...

Objectives: Craniopharyngioma is a benign tumour of the suprasellar region that is associated with increased morbidity and mortality in comparison to other causes of hypopituitarism. We aimed to establish the mode of presentation, investigations, treatment outcomes, mortality and subjective improvement in patients with craniopharyngioma in a single institution over 10 years.Design: Retrospective case notes review of patients with Craniopharyngioma on end...

Introduction: We submit a rare presentation of pheaochromocytoma in pregnanacy, diagnosed just before delivery, posing complex management difficulties.Case presentationA 24-year-old primipara had headache, hypertension and visual disturbance but without any palpitations or diaphoresis. Her headache was persistent during pregnancy. Investigations at 39 weeks of gestation showed normal plasma Normetadrenaline at 885.0 (120–1180)...

Introduction: Hypothalamic–pituitary sarcoidosis is uncommon and affects <10% of patients with neurosarcoidosis. It presents a diagnostic challenge. We present a case of isolated central hypoadrenalism presenting as the sole manifestation of neurosarcoidosis.Case history: A 76-year-old man with recently diagnosed primary hypothyroidism presented with weight loss, increasing lethargy and fatigue. Physical exam revealed inguinal lymhadenopathy. St...

Background: Empagliflozin is a sodium-glucose-cotransporter-2 that improves cardiovascular risk and weight loss in patients with type 2 diabetes. Polycystic ovary syndrome (PCOS) is associated with obesity and increased cardiovascular risk; therefore, empagliflozin may be of benefit in PCOS.Methods: A randomised, open-label study in 40 overweight and obese women with PCOS treated with either empagliflozin 25 mg or metformin 1500mg daily for 12 weeks....

Introduction: We submit a rare presentation of round blue cell pituitary tumour complicated by cranial diabetes insipidus following transphenoidal surgery.Case history: 47-year-old lady with severe headache was diagnosed with a 10 mm non functioning pituitary macro adenoma. Initial plan for conservative management was revised as she developed sixth cranial nerve palsy, bi temporal hemianopia and rapidly enlarging pituitary tumour to 20×18×19 mm...

Patients and methods: 190 acromegalic patients are registered in the National Diabetes Center, 60 were enrolled in the study. They were randomly selected by simple sampling technique according to their scheduled visits monthly to receive - long acting repeatable octreotide injections (LAR).Results: Table 1 Demographic data of the enrolled acromegalic patients.</c...

Introduction: We evaluated Twin Precision Treatment (TPT) approach, a cluster of Internet of Things (IoT) and Artificial Intelligence (AI), validated biosensors and Continuous Glucose Monitoring (CGM) through Ambulatory Glucose Profile (AGP) integrated with machine learning algorithms, enabling physicians to empower patients to reverse diabetes.Methods: 64 T2DM (19 males, 45 female), registered on Twin Health TM service, managed by standard care of appro...

Background: Turner syndrome is a lifelong condition that requires lifelong engagement with health services. The Paediatric Endocrinologist has a role in developing a plan for transition and establishing follow-up in an adult clinic. A clinic proforma outlining expected investigations during transition has been in use in the Glasgow Turner clinic since 2015 based on the recommendations of the Turner Syndrome Study Group. More recently The Endocrine Society Transition Toolkit ha...