Endocrine Abstracts

In Ireland, we are devolving management of diabetes to primary care. Recent studies highlight the importance of early glycemic (metabolic memory) & multifactorial control. Our hospital‘new’patient waiting lists average 18 months and for ‘best practice’, this is “time lost”. We established a pilot program for a rapid assessment to reduce waiting times and ensure specialist input. This is a retrospective review of our 50 patients thus far. 30% w...

Adolescence is specific periods with physical, physiological, behavioral and social changes. Dietary intakes and food habits are important factors in determining those well-balanced changes during this period of life).336 high school girls (168 urban and 168 rural) in 14–18 years old were randomly selected to determine their daily dietary patterns, in comparing the differences between rural and urban adolescent girls.Data were...

Background: Lymphocytic hypophysitis is a rare pathology of the pituitary gland which presents with features of hypopituitarism due to inflammation of the pituitary gland and/or a sellar mass lesion. It is an autoimmune condition and is the most frequent histopathological subtype of primary hypophysitis. Given that it is relatively rare, diagnosis and treatment can be challenging.Case Description: A 60-years-old female with history of type 2 diabetes ref...

Introduction: Hypercalcaemia is a relatively common medical condition affecting around 1% of the general population. Around 90% of the cases are due to either primary hyperparathyroidism (PHPT) or malignancy. Familial hypocalciuric hypercalcaemia (fHH) is a rare autosomal dominant condition that can result in hypercalcaemia. It has an estimated prevalence of1 in 78 000. In most of the cases, fHH is due to a mutation in the calcium-sensing receptor gene (CaSR). Other rare cases...

Introduction: Endocrine late effects can manifest in hemopoietic stem cell transplantation survivors who were exposed to myelosuppressive conditioning treatment. These include dysfunction of the hypothalamic/pituitary, thyroid, and gonads leading to premature ovarian insufficiency and primary amenorrhoea. In addition, metabolic dysregulation and increased risk of diabetes have been observed in these patients. The investigation for primary amenorrhoea in this condition can rare...

Introduction: The uncertainty surrounding the optimal dose to rectify severe vitamin D deficiency (VDD) necessitates further investigation.Aim: To review and analyze various vitamin D (VD) supplementation doses, durations, and their effects on 25-hydroxyvitamin D (25OHD) levels, along with their biochemical and clinical outcomes, in the management of VDD.Methods: We reviewed intervention studies targeting VDD from databases (PubMed...

Introduction: The relationship between early puberty and abnormal bone health has garnered significant research attention, with varying outcomes. Objectives: This review systematically examines studies up to March 2023 to determine whether early puberty is associated with abnormal bone health, specifically low bone mineral density (BMD), osteopenia, and osteoporosis. We analyze and summarize research articles (n=25) to elucidate the potential li...

We conducted a longitudinal study on 95 children presented to pediatric clinic with short stature. Children were classified to low IGF1 (IGF1SDS <-1) (n=25) and normal IGF1 (IGF1SDS >-1) (n=70) and treated with human GH (0.03: 0.05 mg/kg/day) for 2 years. Anthropometrics data (HtSDS, difference from mid-parental height SDS (MPHSD), BMISDS, bone age and IGF1 level were studied for 2 years.Results: At presentation, the age, bone a...

The Relationship between Precocious/Early Puberty and Obesity with Metabolic Abnormalities: A Comprehensive ReviewIntroduction: The impact of pubertal timing on the development of obesity and metabolic abnormalities has been the subject of extensive research with variable outcomes. Objective: We systematically reviewed studies (Medline, Pubmed, Google scholar, and Web of Science) 2000 until March 2023 evaluating the relation betwee...

This study aimed to explore the prevalence of distinct Metabolic Syndrome (MetS) components and plasma AIP among obese children and adolescents, and to evaluate their anthropometric measures in comparison to their parents, thereby considering genetic and environmental influences.Methodology: Anthropometric and biochemical profiles of 91 randomly selected obese children and young adolescents (mean age: 10.5&pm;2.7 years) were meticulously analyzed. This c...